AI Article Synopsis
- A new granaticin analogue (compound 1) and its hydrolysis product (compound 2) were identified from Streptomyces sp. CPCC 200532, with their structures determined through spectroscopic analysis.
- Compound 1 is as an intermediate in the production of granaticin B and has similar cytotoxic effects on the cancer cell line HCT116, but reduced effects on A549, HeLa, and HepG2 cell lines.
- Compound 2 has lower cytotoxicity than compound 1 across all cancer cell lines tested.
Article Abstract
A new granaticin analogue and its hydrolysis product were isolated from Streptomyces sp. CPCC 200532. Their structures were determined to be 6-deoxy-13-hydroxy-8,11-dione-dihydrogranaticins B (1) and A (2), respectively, by detailed analysis of spectroscopic data. Compound 1 was regarded as an intermediate in granaticin biosynthesis, as it was bioconvertable to granaticin B. Compared to granaticin B, 1 showed similar cytotoxicity against cancer cell line HCT116, but decreased cytotoxicity against cancer cell lines A549, HeLa, and HepG2. Compound 2 displayed lower cytotoxicity than 1 against all four cancer cell lines tested.
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| http://dx.doi.org/10.1021/np500138k | DOI Listing |
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