Leprosy is endemic in Senegal. In 2011, there were 73 new cases reported in Dakar. The circumstances of discovery are often dermatologic or neurologic. Few case reports describe an association with chronic inflammatory colitis, probably fortuitous. We report the case of a 30-year-old woman who had a tuberculoid leprosy revealed by active ulcerative colitis. Treatment according to the WHO protocol of leprosy, combined with corticosteroids and then methotrexate, resulted in healing of the leprosy and remission of the colitis.
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http://dx.doi.org/10.1684/mst.2014.0365 | DOI Listing |
iScience
March 2025
Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Alveolar macrophages (AMs) are essential for maintaining lung homeostasis. However, their roles in respiratory infections have been controversial because the methods of depleting them have often suffered from poor cell selectivity. To resolve this problem, we here used VeDTR technology to generate a transgenic mouse line in which AMs can be specifically depleted using diphtheria toxin.
View Article and Find Full Text PDFPediatr Dermatol
March 2025
Department of Dermatology, Venereology, Leprosy, Osmania Medical College, Hyderabad, Telangana, India.
A 12-year-old female presented with multiple milia and skin-coloured papules over face and neck, follicular atrophoderma and hypotrichosis. Family history of similar complaints present in mother and maternal aunt. Biopsy from the skin-coloured papule revealed trichoepithelioma.
View Article and Find Full Text PDFCell Mol Immunol
March 2025
Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Xenophagy plays a crucial role in restraining the growth of intracellular bacteria in macrophages. However, the machinery governing autophagosome‒lysosome fusion during bacterial infection remains incompletely understood. Here, we utilize leprosy, an ideal model for exploring the interactions between host defense mechanisms and bacterial infection.
View Article and Find Full Text PDFMolecules
February 2025
Department of Chemistry and Cosmetics, Jeju Inside Agency and Cosmetic Science Center, Jeju National University, Jeju 63243, Republic of Korea.
Drug repurposing is a cost-effective and innovative strategy for identifying new therapeutic applications for existing drugs, thereby shortening development timelines and accelerating the availability of treatments. Applying this approach to the development of cosmeceutical ingredients enables the creation of functional compounds with proven safety and efficacy, adding significant value to the cosmetic industry. This study evaluated the potential of rifampicin, a drug widely used for the treatment of tuberculosis and leprosy, as a cosmeceutical agent.
View Article and Find Full Text PDFPLOS Glob Public Health
February 2025
Department of Health Studies, College of Human Sciences, University of South Africa, Pretoria, South Africa.
Drug-resistant tuberculosis remains a persistent public health threat. Maximizing successful treatment completion is a global health priority and a focus of the End TB strategy. Despite the implementation of programmatic management for drug-resistant tuberculosis in Ethiopia, there is limited understanding of the barriers related to successful treatment completion among Ethiopian patients.
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