AI Article Synopsis
- Parkinson's disease (PD) is a prevalent central nervous system disorder mainly affecting older adults, with genetic factors playing a significant role in its development.
- Recent research highlights the importance of mitochondrial dysfunction, linked to variations and mutations in mitochondrial DNA (mtDNA), in the pathogenesis of PD.
- This review discusses and evaluates the evidence supporting mtDNA variations as key contributors to the onset and progression of Parkinson's disease.
Article Abstract
Parkinson's disease (PD) is a common disorder of the central nervous system in the elderly. The pathogenesis of PD is a complex process, with genetics as an important contributing factor. This factor may stem from mitochondrial gene variations and mutations as well as from nuclear gene variations and mutations. More recently, a particular role of mitochondrial dysfunction has been suggested, arising from mitochondrial DNA variations or acquired mutations in PD pathogenesis. The present review summarizes and weighs the evidence in support of mitochondrial DNA (mtDNA) variations as important contributors to the development and course of PD.
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| http://dx.doi.org/10.1016/j.jns.2014.07.067 | DOI Listing |
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