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Convective assembly of silica colloidal particles inside photonic integrated chip-based microfluidic systems for gas sensing applications.
Nanoscale
September 2024
Center for Photonic Science and Engineering, Skolkovo Institute of Science and Technology, 30 Bld. 1 Bolshoy Boulevard, 121205, Russia.
Article Synopsis
- Optofluidics combines microfluidics and photonics, presenting exciting opportunities for gas sensing technologies.
- This study explores the creation of monolayer structures on a silicon nitride substrate, achieving a surface coverage of 59% through a microfluidic process.
- The research highlights how linking these monolayers with a photonic integrated chip can enhance gas detection capabilities.
Is Feto-Maternal Transfusion after Cesarean Delivery Different in Singleton and Twin Pregnancy?
J Clin Med
June 2024
Department of Obstetrics, Perinatology and Neonatology, Center of Postgraduate Medical Education, 01-813 Warsaw, Poland.
The aim of the study was to investigate if feto-maternal transfusion was related to the size of the fetal-maternal interface, and, therefore, was larger in twin pregnancy in comparison with singleton pregnancy. : Blood samples from women with singleton ( = 11), and monochorionic ( = 11) and dichorionic ( = 13) twin gestations were tested. Flow cytometry tests with hemoglobin F, glycophorin A, and hemoglobin F and carbonic anhydrase simultaneous staining were used to detect fetal red blood cells and maternal F cells.
View Article and Find Full Text PDFDiagnostic Role of Cell-Free miRNAs in Identifying Placenta Accreta Spectrum during First-Trimester Screening.
Int J Mol Sci
January 2024
Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Ac. Oparina 4, 117997 Moscow, Russia.
Placenta accreta spectrum (PAS) is a severe complication of pregnancy associated with excessive invasion of cytotrophoblast cells at the sites of the endometrial-myometrial interface and the myometrium itself in cases of adherent (creta) and invasive (increta and percreta) forms, respectively. This leads to a high risk of massive blood loss, maternal hysterectomy, and preterm birth. Despite advancements in ultrasound protocols and found associations of alpha-fetoprotein, PAPP-A, hCG, PLGF, sFlt-1, IL-8, and IL-33 peripheral blood levels with PAS, there is a high need for an additional non-invasive test to improve the diagnostic accuracy and to select the real PAS from the suspected ones in the first-trimester screening.
View Article and Find Full Text PDFMultiomic spatial landscape of innate immune cells at human central nervous system borders.
Nat Med
January 2024
Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Article Synopsis
- The human central nervous system (CNS) has a diverse immune compartment that includes various cell populations, notably microglia (brain macrophages) and CNS-associated macrophages (CAMs), which are less common and not well studied.
- Researchers used advanced techniques like single-cell RNA sequencing and spatial transcriptomics to analyze over 356,000 transcriptomes from 102 individuals, revealing insights into the presence and variability of CAM subclasses in different conditions.
- The study also examined myeloid cell types in glioblastoma samples, finding that the immune responses to hypoxia differ significantly between cancer-affected areas and healthy brain regions, emphasizing the complexity of the brain's immune system.
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal-fetal interface following SARS-CoV-2 infection.
Nat Cell Biol
July 2023
Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
During pregnancy the maternal-fetal interface plays vital roles in fetal development. Its disruption is frequently found in pregnancy complications. Recent studies show increased incidences of adverse pregnancy outcomes in patients with COVID-19; however, the mechanism remains unclear.
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