Introduction: Subtrochanteric femur fractures remain challenging injuries to treat. Historically, varus malreduction has been linked to the development of nonunion; however, there is a paucity of literature evaluating the impact of sagittal plane malreduction. The purpose of this study was to evaluate the influence of coronal and sagittal plane malreductions on time to union of subtrochanteric femur fractures treated with an intramedullary device.
Methods: A retrospective study was performed of all sub-trochanteric fractures (AO/OTA type 32) treated at a single institution. Inclusion criteria consisted of: 1. 18 or more years of age, and 2. fracture stabilization using an intramedullary device. All patients included were followed to union or revision surgery. Radiographic evidence of healing was defined as bridging callus on three of four cortices on AP and lateral views. Delayed union was defined as lack of radiographic healing by 4 months postoperatively and nonunion as lack of healing by 6 months. The definition of malreduction was coronal or sagittal plane deformity greater than 10° at the fracture site.
Results: Thirty-five patients met inclusion criteria; 20 men and 15 women with an average age of 55 years (range 19 to 100 years). Mean clinical follow up was 7 months (range 3 to 18 months). Thirty-four of 35 fractures (97%) healed without need for additional surgery. Twenty-one of the 35 fractures (60%) healed within 4 months of surgery. Thirteen fractures (37%) had delayed union, and 1 (2.9%) developed nonunion requiring reoperation. Seven of 35 fractures (20.0%) had a malreduction of greater than 10°, defined as varus (2 fractures), flexion (4 fractures), or both (1 fracture). Of the seven fractures with a malreduction, all (100%) developed a delayed (6) or nonunion (1). Of the 28 fractures without malreduction, 21 (75%) healed within 4 months, 7 (25%) had a delayed union, and none had a nonunion. The presence of a malreduction greater than 10° in any plane resulted in a significantly higher rate of delayed or nonunion (p = 0.0005).
Conclusion: For patients with subtrochanteric fractures treated with an intramedullary device, malreduction in any plane of greater than 10° resulted in a significantly increased rate of delayed or nonunion or both.
Download full-text PDF |
Source |
---|
J Appl Microbiol
March 2024
School of Biological Sciences, Queen's University Belfast, 19 Chlorine Gardens, Belfast BT9 5DL, United Kingdom.
Aims: This study aimed to develop a new bioinformatic approach for the identification of novel antimicrobial peptides (AMPs), which did not depend on sequence similarity to known AMPs held within databases, but on structural mimicry of another antimicrobial compound, in this case an ultrashort, synthetic, cationic lipopeptide (C12-OOWW-NH2).
Methods And Results: When applied to a collection of metagenomic datasets, our outlined bioinformatic method successfully identified several short (8-10aa) functional AMPs, the activity of which was verified via disk diffusion and minimum inhibitory concentration assays against a panel of 12 bacterial strains. Some peptides had activity comparable to, or in some cases, greater than, those from published studies that identified AMPs using more conventional methods.
Front Pharmacol
June 2022
Department of Neuroscience, University of Naples "Federico II", Naples, Italy.
Pathogenic variants in KCNQ2 encoding for Kv7.2 potassium channel subunits have been found in patients affected by widely diverging epileptic phenotypes, ranging from Self-Limiting Familial Neonatal Epilepsy (SLFNE) to severe Developmental and Epileptic Encephalopathy (DEE). Thus, understanding the pathogenic molecular mechanisms of KCNQ2 variants and their correlation with clinical phenotypes has a relevant impact on the clinical management of these patients.
View Article and Find Full Text PDFFront Microbiol
November 2018
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, China.
Duck hepatitis A virus 1 (DHAV-1) belongs to the genus in the family . Little research has been carried out on the non-structural proteins of this virus. This study reports that 2A1 protein, the first non-structural protein on the DHAV-1 genome, has a ribosomal "skipping" function mediated by a "-GxExNPGP-" motif.
View Article and Find Full Text PDFJ Biotechnol
April 2015
Bioprocessing Technology Institute, A*STAR (Agency for Science, Technology and Research), 20 Biopolis Way, #06-01 Centros, Singapore 138668, Singapore; Department of Chemical and Biomolecular Engineering, Synthetic Biology Research Consortium, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. Electronic address:
Engineered antibody fragments often contain natural or synthetic linkers joining the antigen-binding domain and multimerization regions, and the roles of these linkers have largely been overlooked. To investigate linker effects on structural properties and functionality, six bivalent cytotoxic antibody fragments with of linkers of varying flexibility and length were constructed: (1) 10-AA mouse IgG3 upper hinge region, (2) 20-AA mouse IgG3 upper hinge region repeat, (3) 10-AA glycine and serine linker, (4) 20-AA glycine and serine linker repeat, (5) 21-AA artificial linker, and (6) no-linker control. Interestingly, a higher cytotoxicity was observed for fragments bearing the rigid short linkers compared to the flexible longer linkers.
View Article and Find Full Text PDFEquine Vet J Suppl
August 2006
Equine Science Division, Hidaka Training and Research Center, Japan Racing Association, Urakawa-gun, Hokkaido, Japan.
Reasons For Performing Study: In man, muscle protein synthesis is accelerated by administering amino acids (AA) and glucose (Glu), because increased availability of amino acids and increased insulin secretion, is known to have a protein anabolic effect. However, in the horse, the effect on muscle hypertrophy of such nutrition management following exercise is unknown.
Objectives: To determine the effect of AA and Glu administration following exercise on muscle protein turnover in horses.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!