Three new glycoalkaloids, N-formyl-asimilobine-2-O-β-D-glucoside (1), (-)-1-O-β-D-glucoside-8-oxotetrahydropalmatine (2), and 1-N-monomethylcarbamate-argentinine-3-O-β-D-glucoside (3) were isolated from tubers of Stephania succifera. The structures were established based on spectroscopic analysis, and the antimicrobial activities of the three glycoalkaloids are reported.
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http://dx.doi.org/10.1007/s12272-014-0467-5 | DOI Listing |
Nat Prod Res
October 2024
College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Nat Prod Res
November 2023
Department of Pharmacy, Wuhan First Hospital, Wuhan, China.
A new morphinan alkaloid (6, 9, 13 , 14)-6-O-acetyl-7,8-Didehydro-4-hydroxy-3,7-dimethoxymorphinan-6-ol (), and a new naturally occurring cularine alkaloid ()-2, 3, 12, 12a-tetrahydro-5, 6, 9, 10-tetramethoxy-1-methyl-1H-[1]benzoxepino[2, 3, 4-]isoquinoline(), along with four known alkaloids were isolated from the roots of . The structures of these compounds were elucidated based on spectroscopic data analyses. Cytotoxic activities of the compounds against three human cancer cell lines (A549, MCF-7 and SW480) were also evaluated.
View Article and Find Full Text PDFAppl Biochem Biotechnol
June 2024
Central Research Laboratory and Department of Bio-sciences and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, 133207, India.
In pursuit of a novel effective treatment for prostate cancer, methanolic extract of Stephania glabra tubers (Sg-ME) was utilized to fabricate silver (Sg-AgNP), copper oxide (Sg-CuONP), and silver-copper bimetallic nanoparticles (Sg-BNP). The characterization of the nanoparticles confirmed spherical shape with average diameters of 30.72, 32.
View Article and Find Full Text PDFHeliyon
May 2023
College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, 530200, China.
The genus , which is rich in alkaloids, has been used as a traditional medicine or folklore herb against numerous ailments in China. However, the understanding of the variation within the genus is obscure, which limits the optimal utilization of the genus. An evaluation of the variation within the genus would help screen the ideal genotypes for drug utilization.
View Article and Find Full Text PDFInflammopharmacology
August 2023
School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) have high mortality rates. Though corticosteroids are commonly used for the treatment of these conditions, their efficacy has not been conclusively demonstrated and their use can induce various adverse reactions. Hence, the application of corticosteroids as therapeutic modalities for ALI/ARDS is limited.
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