Very little is known about the transcription factor network that regulates the development of intestinal intraepithelial lymphocytes (IELs). In this issue of Immunity, Klose et al. (2014b) and Reis et al. (2014) demonstrate an essential role for T-bet in regulating the CD8αα IEL differentiation program.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290465 | PMC |
| http://dx.doi.org/10.1016/j.immuni.2014.08.003 | DOI Listing |
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