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Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones. | LitMetric
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Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones.

Eric B Lindgren Monique A de Brito Thatyana R A Vasconcelos Manuel O de Moraes Raquel C Montenegro Julliane D Yoneda Kátia Z Leal

Eur J Med Chem

Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal Fluminense, Outeiro de São João Batista s/n°, 24020-141 Niterói, RJ, Brazil. Electronic address:

Published: October 2014

Benzothiazole hydrazones have been synthesized and evaluated for their in vitro antiproliferative activity against three human cancer cell lines: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). The good cytotoxicity for the three cancer cell lines and theoretical profile of compounds 3o and 3p pointed them as promising lead molecules for anticancer drug design.

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http://dx.doi.org/10.1016/j.ejmech.2014.08.039DOI Listing

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