AI Article Synopsis
- Lysyl oxidase like-2 (LOXL2) is an enzyme related to the lysyl oxidase family that plays a key role in crosslinking collagen and elastin in the extracellular matrix (ECM).
- LOXL2 is thought to influence both extracellular and intracellular cell signaling pathways.
- Abnormal regulation of LOXL2 has been associated with various diseases, including cancer, angiogenesis (new blood vessel formation), fibrosis, and heart conditions.
Article Abstract
Lysyl oxidase like-2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises Cu(2+)- and lysine tyrosylquinone (LTQ)-dependent amine oxidases. LOXL2 is proposed to function similarly to LOX in the extracellular matrix (ECM) by promoting crosslinking of collagen and elastin. LOXL2 has also been proposed to regulate extracellular and intracellular cell signaling pathways. Dysregulation of LOXL2 has been linked to many diseases, including cancer, pro-oncogenic angiogenesis, fibrosis and heart diseases. In this review, we will give an overview of the current understandings and hypotheses regarding the molecular functions of LOXL2.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309629 | PMC |
| http://dx.doi.org/10.1016/j.bioorg.2014.07.003 | DOI Listing |
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