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| http://dx.doi.org/10.1111/2049-632X.12213 | DOI Listing |
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Antibodies directed against bacterial antigens in sera of Polish patients with primary biliary cholangitis.
Front Cell Infect Microbiol
January 2025
Clinic of Polish Gastroenterology Foundation, Warsaw, Poland.
Background: Primary biliary cholangitis (PBC) is a cholestatic, autoimmune liver disease with the presence of characteristic autoantibodies. The aim of the work was to determine the level of antibodies directed against bacterial antigens: (anti-anti), (anti-), (anti- ) and () in sera of PBC patients. We also performed studies on the impact of the bacterial peptides on the specific antigen-antibody binding.
View Article and Find Full Text PDFOverexpressing the ClpC AAA+ unfoldase accelerates developmental cycle progression in .
mBio
January 2025
Department of Pathology, Microbiology, and Immunology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
is an obligate intracellular bacterium that undergoes a complex biphasic developmental cycle, alternating between the smaller, infectious, non-dividing elementary body (EB) and the larger, non-infectious but dividing reticulate body. Due to the differences between these functionally and morphologically distinct forms, we hypothesize protein degradation is essential to chlamydial differentiation. The bacterial Clp system, consisting of an ATPase unfoldase (e.
View Article and Find Full Text PDFIntranasal immunization with CPAF combined with ADU-S100 induces an effector CD4 T cell response and reduces bacterial burden following intravaginal infection with Chlamydia muridarum.
Vaccine
January 2025
Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection globally, and a vaccine is urgently needed to stop transmission and disease. Chlamydial Protease Activity Factor (CPAF) is an immunoprevalent and immunodominant antigen for CD4 T cells and B cells, which makes it a strong vaccine candidate. Due to the tolerogenic nature of the female genital tract (FGT) and its lack of secondary lymphoid tissue, effective induction of protective cell-mediated immunity will likely require potent and safe mucosal adjuvants.
View Article and Find Full Text PDFTail-specific protease is an essential virulence factor that mediates the differentiation of elementary bodies into reticulate bodies.
Infect Immun
December 2024
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Tail-specific proteases (Tsp) are members of a widely distributed family of serine proteases that commonly target and process periplasmic proteins in Gram-negative bacteria. The obligately intracellular, Gram-negative encode a highly conserved Tsp homolog whose target and function are unclear. We identified a mutant with a nonsense mutation in .
View Article and Find Full Text PDFArticle Synopsis
- Chlamydia trachomatis (Ct) is the most prevalent bacterial STI worldwide, highlighting the urgent need for an effective vaccine.
- The study focuses on Chlamydial Protease Activity Factor (CPAF), identified as a promising antigen for vaccine development due to its strong immune response in T and B cells.
- Researchers tested different mucosal adjuvants, finding that intranasal vaccination with CPAF and a specific adjuvant (CDA) was safe and effective in reducing infection in mice, indicating potential for a new Chlamydia vaccine.
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