Rectal cancer is a major health problem around the world, representing about one-third of the total colorectal cancer cases. Because of its anatomical location, there is a higher risk of local recurrence, and treatment often requires a complex multidisciplinary approach which includes neoadjuvant radiotherapy, chemotherapy, and a radical surgical procedure that commonly leads to a permanent colostomy. The cure rate with this strategy is good, with some patients having no residual disease in the surgical specimen. While the prognosis for those patients is excellent, their quality of life is permanently compromised. In this article, we review risks and benefits of the standard treatment approach and compare standard treatment with alternative methods aimed at rectal preservation.
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Effects of immersive virtual reality-based action observation training integrated with focal muscle vibration on upper extremity in a patient with chronic disability following stroke: a single-subject study.
Physiother Theory Pract
March 2025
Physiotherapy Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Background: The association of different sensory inputs enhances brain plasticity in patients after stroke, but no studies have associated Action Observation Training (AOT) delivered in immersive virtual reality (VR) with Focal Vibration (FV) to elicit a kinesthetic illusion coherent with the observed task to improve motor function.
Objective: The study aimed to evaluate the feasibility of AOT delivered in immersive VR integrated with FV of upper limb muscles on manual dexterity in patients with chronic stroke.
Methods: A single-subject study was conducted (A-B design).
Neonatal lupus erythematosus: an acquired autoimmune disease to be taken seriously.
Ann Med
December 2025
Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
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Parallelized Droplet Vitrification for Single-Run Vitrification of Hepatocytes from an Entire Rat Liver.
ACS Appl Mater Interfaces
March 2025
Center for Engineering in Medicine and Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States.
Drug discovery pipelines rely on the availability of isolated primary hepatocytes for investigating potential hepatotoxicity prior to clinical application. These hepatocytes are isolated from livers rejected for transplantation and subsequently cryopreserved for later usage. The gold standard cryopreservation technique, slow-freezing, is a labor-intensive process with significant poststorage viability loss.
View Article and Find Full Text PDF[Combining the benefits of aligners with those of fixed appliance treatments – Part 2].
Orthod Fr
March 2025
41 rue du Rempart, 59300 Valenciennes, France
Introduction: Aligners are presented as an aesthetic and simple solution capable of treating a wide range of malocclusions. However, they require numerous auxiliaries that are often complex to implement and unesthetic attachments to compensate for their inability in reproducing the simulated movements.
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[Early conversion to belatacept post-transplantation: state of the art and expert opinion].
Nephrol Ther
March 2025
Néphrologie, hémodialyse, aphérèse et transplantation, CHU Grenoble Alpes, La Tronche, France
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- The standard immunosuppressive regimen after organ transplantation typically includes drugs like tacrolimus, mycophenolic acid, and corticosteroids, which can cause side effects like kidney damage.
- Belatacept offers a promising alternative by blocking a key costimulation pathway, showing improved kidney function and reduced donor-specific antibodies in early studies, despite a higher risk of acute rejections.
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