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A Tale of Two Cysts: A Histopathological Case Report of Epithelial and Mesothelial Splenic Cysts.
Cureus
December 2024
Research Institute, Medical University of Pleven, Pleven, BGR.
Splenic cysts are rare medical conditions, and their incidence is dominated by parasitic types. Non-parasitic splenic cysts, whether true cysts (with a cellular lining of the cystic wall) or pseudocysts (without a cellular lining), are significantly rarer than parasitic ones. Their etiology is not fully established, with fetal remnant development, metaplasia, and mesothelial invagination being widely accepted possible mechanisms.
View Article and Find Full Text PDFTransvaginal Evisceration in a Patient With Rectovaginal Prolapse: A Twist in the Tale.
Cureus
December 2024
General Surgery, Hospital do Espírito Santo de Évora, Évora, PRT.
Transvaginal evisceration is a rare, potentially life-threatening condition involving herniation of intra-abdominal contents, typically the small bowel, through a defect in the vaginal wall. Most commonly observed in postmenopausal women with a history of pelvic surgery or trauma, it necessitates prompt surgical intervention. We report a unique case of transvaginal evisceration in a 67-year-old postmenopausal female with rectovaginal prolapse following minor trauma.
View Article and Find Full Text PDFMechanistic insights into cardiac regeneration and protection through MEIS inhibition.
Turk J Biol
October 2024
Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, İstanbul, Turkiye.
Article Synopsis
- MEIS1 is a key regulator in stopping cardiomyocyte cell division and is a potential target for heart-related therapies.
- Inhibition of MEIS1 through new small molecules (MEISi-1 and MEISi-2) boosts the growth and division of neonatal cardiomyocytes significantly compared to untreated cells.
- MEIS1 inhibition not only reduces the expression of certain target genes but also enhances important cardiac-specific gene expression, suggesting these inhibitors could play a vital role in heart regeneration treatments.
Susac's Syndrome: A Tale of Disability Due to Late Recognition.
Cureus
November 2024
Neurology, King's College Hospital, Dubai, ARE.
Susac's syndrome is a rare inflammatory microangiopathy characterized by the triad of retinopathy, encephalopathy, and hearing loss. The syndrome causes recurrent microinfarcts in these organs, which in turn manifests with repeated attacks of visual field loss, hearing loss and tinnitus, and various brain syndromes. These often lead to the significant accumulation of disability over time, particularly if there is a delay or failure in diagnosis.
View Article and Find Full Text PDFDiagnostic enigma of pulmonary hypertension: Tale from a series of three patients.
Med J Armed Forces India
December 2024
Consultant (Radiodiagnosis), Medica Super Specialty Hospital, Kolkata, India.
Pulmonary hypertension (PH) is a complex condition with multiple etiological factors. The ability to identify a potential underlying cause is crucial for accurate diagnosis, patient management, and prognostication. This article presents a series of three patient cases to illustrate the enigmatic nature of PH diagnosis.
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