Synthesis of the erythrina alkaloid erysotramidine.

J Org Chem

Laboratoire de Méthodologie et Synthèse de Produits Naturels, Université du Québec à Montréal , C.P. 8888, Succ. Centre-Ville, Montréal, H3C 3P8 Québec, Canada.

Published: September 2014

A concise synthesis of erysotramidine (an alkaloid belonging to the erythrina family) was achieved starting with an inexpensive phenol and amine derivative. The synthesis is based on oxidative phenol dearomatizations mediated by a hypervalent iodine reagent and includes a novel route to a key indolinone moiety.

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http://dx.doi.org/10.1021/jo501583cDOI Listing

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