A concise synthesis of erysotramidine (an alkaloid belonging to the erythrina family) was achieved starting with an inexpensive phenol and amine derivative. The synthesis is based on oxidative phenol dearomatizations mediated by a hypervalent iodine reagent and includes a novel route to a key indolinone moiety.
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http://dx.doi.org/10.1021/jo501583c | DOI Listing |
Microbiol Immunol
November 2024
Virus Research Center, Clinical Research Division, Sendai Medical Center, National Hospital Organization, Sendai, Japan.
Human parainfluenza viruses (hPIVs) are causative agents of upper and lower respiratory tract infections and they have four serotypes. The virion surface displays hemagglutinin-neuraminidase (HN), having hemagglutinating (HA) and neuraminidase (NA) activities in a single molecule. The HA activity binds the virion to sialic acid on the viral receptor on host cells and the NA releases the progeny viruses from the cell surface.
View Article and Find Full Text PDFVet Res Commun
December 2024
Universidade Federal Da Grande Dourados (UFGD), Rua João Rosa Góes, 1761 - Vila Progresso, Dourados, MS, 79825-070, Brasil.
This study aimed to assess the leaf aqueous extract composition of Erythrina crista-galli and the effects of its inclusion on the diet of red-eye tetra (Moenkhausia forestii), concerning enzyme content of digestive, hepatic, and oxidation metabolism and pigmentation. Fish (1.78 ± 0.
View Article and Find Full Text PDFInt J Mol Sci
August 2024
Development and Innovation in Alternative Proteins Group (INNOVAPROT), Institute of Food Science Research (CIAL, CSIC-UAM, CEI UAM + CSIC), Nicolás Cabrera, 28049 Madrid, Spain.
Amidst increasing awareness of diet-health relationships, plant-derived bioactive peptides are recognized for their dual nutritional and health benefits. This study investigates bioactive peptides released after Alcalase hydrolysis of protein from chachafruto (), a nutrient-rich South American leguminous plant, focusing on their behavior during simulated gastrointestinal digestion. Evaluating their ability to scavenge radicals, mitigate oxidative stress, and influence immune response biomarkers, this study underscores the importance of understanding peptide interactions in digestion.
View Article and Find Full Text PDFDrug Des Devel Ther
September 2024
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Padjadjaran University, Sumedang, Indonesia.
Background: The twigs and roots of (Hassk). Merr. Was reported to possess antidiabetic activity by reducing the activity of α-glucosidase and α-amylase.
View Article and Find Full Text PDFPathol Res Pract
October 2024
Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan.
The mesothelium is a non-adhesive protective surface that lines the serosal cavities and organs within the body. The glycocalyx is a complex structure that coats the outer layer of the mesothelium. However, due to the limitations of conventional fixation techniques, studies on glycans are limited.
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