AI Article Synopsis
- Methotrexate is a versatile drug used to treat conditions like psoriasis and rheumatoid arthritis, but its use is limited due to concerns about liver damage (hepatotoxicity).
- The article aims to outline the risk factors, causes, and guidelines for monitoring hepatotoxicity related to methotrexate based on US, UK, and European standards.
- It also briefly discusses how methotrexate works and the implications of using it in high doses.
Article Abstract
Methotrexate is effective not only in treating psoriasis and rheumatoid arthritis but also various other disorders. The use of methotrexate has been somewhat limited by concerns regarding its adverse effects, including its potential for hepatotoxicity. The purpose of this article is to provide an overview of methotrexate-associated hepatotoxicity, including risk factors, pathogenesis and recommendations for monitoring it by US, UK and European guidelines, as well as providing a brief overview of its mechanism of action and of high-dose methotrexate.
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| http://dx.doi.org/10.1111/1751-2980.12184 | DOI Listing |
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