Clinical experience has indicated that many complications during treatment with the Ilizarov method, and mainly tract infection, are related to decreased wire tension. The aim of this work was to evaluate biomechanically a novel wire tensioning and clamping system that will minimise or even diminish the reduction of the wire pretension during treatment. The proposed approach is based on threading of the wire end in a sufficient length. The wire pretension is applied by twisting a nut on the threaded part of the wires against the ring and is recorded by an incorporated force sensor. For biomechanical evaluation, the frame, consisting of a polyethylene bar, simulating the bone fragment, suspended on two rings, was subjected to a dynamic load of 0-800 N at a frequency of 0.5 Hz. After dynamic loading for 20 min, loss of the initial wire pretension for the novel clamping system ranged between 12 and 16%. The average loss for conventionally clamped wires was 75%. The advantages of the novel clamping system were the much greater ability to sustain the transverse load and the easy and effectual wire re-tensioning. Although wire slippage has been avoided with the novel system, wire material yield is still responsible for a pretension loss.
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http://dx.doi.org/10.1007/s00590-014-1518-9 | DOI Listing |
Cells
January 2025
Department of Chemistry, Biology and Biotechnologies, University of Perugia, Via dell'Elce di Sotto 8, 06123 Perugia, Italy.
J Hypertens
December 2024
Institute for Fetology, The First Affiliated Hospital of Soochow University, Jiangsu.
Background: Paternal preconception alcohol exposure affects fetal development; however, it is largely unknown about the influences on offspring vasculature and mechanisms.
Methods: Offspring born form paternal rats treated with alcohol or water before pregnant was raised until 3 months of age. Vessel tone of mesenteric arteries was detected using myograph system; whole-cell calcium channel current in smooth muscle cells was tested using patch-clamp; molecule expressions were detected with real-time PCR, western blotting, and Dihydroethidium (DHE); DNA methylations were determined using targeted bisulfate sequencing assay.
Ann Thorac Surg Short Rep
December 2024
Duke University Medical Center, Durham, North Carolina.
Background: Direct mechanical ventricular actuation (DMVA) with the Anstadt cup is effective for non-blood-contacting biventricular support. Pneumatic regulation of a silicone device augments ventricular pump function. Vacuum attachment facilitates diastolic augmentation critical for biventricular support.
View Article and Find Full Text PDFCell Biosci
January 2025
State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200438, People's Republic of China.
Background: Neuropathic pain resulting from spinal cord injury (SCI) is associated with persistent hyperactivity of primary nociceptors. Anandamide (AEA) has been reported to modulate neuronal excitability and synaptic transmission through activation of cannabinoid type-1 receptors (CB1Rs) and transient receptor potential vanilloid 1 (TRPV1). However, the role of AEA and these receptors in the hyperactivity of nociceptors after SCI remains unclear.
View Article and Find Full Text PDFNat Commun
January 2025
Laboratory of Structural Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Many bacteriophages modulate host transcription to favor expression of their own genomes. Phage satellite P4 polarity suppression protein, Psu, a building block of the viral capsid, inhibits hexameric transcription termination factor, ρ, by presently unknown mechanisms. Our cryogenic electron microscopy structures of ρ-Psu complexes show that Psu dimers clamp two inactive, open ρ rings and promote their expansion to higher-oligomeric states.
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