AI Article Synopsis
- MAPK pathways play a crucial role in various signal transduction processes in eukaryotes, but their connection to light signaling in plants is not well understood.
- Recent research reveals that the MKK3-MPK6 pathway is activated by blue light and operates through the transcription factor MYC2.
- This study demonstrates a feedback loop where MYC2, which is phosphorylated by MPK6, regulates its own expression, highlighting the importance of the MKK3-MPK6-MYC2 module in the seedling development of Arabidopsis thaliana.
Article Abstract
Mitogen-activated protein kinase (MAPK) pathways are involved in several signal transduction processes in eukaryotes. Light signal transduction pathways have been extensively studied in plants; however, the connection between MAPK and light signaling pathways is currently unknown. Here, we show that MKK3-MPK6 is activated by blue light in a MYC2-dependent manner. MPK6 physically interacts with and phosphorylates a basic helix-loop-helix transcription factor, MYC2, and is phosphorylated by a MAPK kinase, MKK3. Furthermore, MYC2 binds to the MPK6 promoter and regulates its expression in a feedback regulatory mechanism in blue light signaling. We present mutational and physiological studies that illustrate the function of the MKK3-MPK6-MYC2 module in Arabidopsis thaliana seedling development and provide a revised mechanistic view of photomorphogenesis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371833 | PMC |
| http://dx.doi.org/10.1105/tpc.114.128702 | DOI Listing |
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