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Improving immunogenicity and efficacy of vaccines for genital herpes containing herpes simplex virus glycoprotein D. | LitMetric

Improving immunogenicity and efficacy of vaccines for genital herpes containing herpes simplex virus glycoprotein D.

Expert Rev Vaccines

522F Johnson Pavilion, Infectious Disease Division, University of Pennsylvania, Philadelphia, PA 19104-6073, USA.

Published: December 2014

AI Article Synopsis

  • * Some studies have shown positive outcomes, including the Herpevac Trial for Women, which used a gD2 vaccine and unexpectedly prevented genital disease caused by HSV-1, but not HSV-2.
  • * The scientific community is divided between abandoning gD2 vaccine efforts and enhancing them based on prior partial successes, with a preference for improving gD2-based vaccines.

Article Abstract

No vaccines are approved for prevention or treatment of genital herpes. The focus of genital herpes vaccine trials has been on prevention using herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) alone or combined with glycoprotein B. These prevention trials did not achieve their primary end points. However, subset analyses reported some positive outcomes in each study. The most recent trial was the Herpevac Trial for Women that used gD2 with monophosphoryl lipid A and alum as adjuvants in herpes simplex virus type 1 (HSV-1) and HSV-2 seronegative women. Unexpectedly, the vaccine prevented genital disease by HSV-1 but not HSV-2. Currently, HSV-1 causes more first episodes of genital herpes than HSV-2, highlighting the importance of protecting against HSV-1. The scientific community is conflicted between abandoning vaccine efforts that include gD2 and building upon the partial successes of previous trials. We favor building upon success and present approaches to improve outcomes of gD2-based subunit antigen vaccines.

Download full-text PDF

Source
http://dx.doi.org/10.1586/14760584.2014.951336DOI Listing

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