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Acute hyperglycemic hyperosmolar syndrome associated with capivasertib, a new, oral targeted therapy for advanced breast cancer.
Am J Emerg Med
December 2024
Department of Emergency Medicine, Sharp Grossmont Hospital, La Mesa, CA, United States.
Capivasertib is a new targeted therapy for the treatment of select cases of hormone receptor positive, HER2 negative advanced breast cancer. Hyperglycemia is a known adverse effect of capivasertib with a 16 % incidence rate, however life-threatening hyperglycemia occurs rarely (incidence 0.3 %).
View Article and Find Full Text PDFTreating deep sternal wound infection with pectoralis major flap transposition: a systemic factor analysis of efficacy and safety.
J Thorac Dis
November 2024
Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- - Deep sternal wound infection (DSWI) is a serious complication after cardiac surgery, and while various treatments exist, many have limitations; thus, the study explores pectoralis major flap transposition (PMFT) as a potential effective method.
- - A study of 785 DSWI patients treated with PMFT found that 90.3% healed successfully, while 9.7% experienced delayed healing or death; additional risk factors for poorer outcomes included diabetes, obesity, and a history of smoking.
- - The results suggest that PMFT is a safe treatment option for DSWI, but patients with specific risk factors should be monitored closely, and further research is recommended to better understand these relationships.
The Role of Dapagliflozin in the Modulation of Hypothermia and Renal Injury Caused by Septic Shock in Euglycemic and Hyperglycemic Rat Models.
Curr Mol Pharmacol
December 2024
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Article Synopsis
- Dapagliflozin, an SGLT2 inhibitor, is effective in reducing sepsis-induced acute kidney injury (AKI) and hypothermia in both normal and diabetic rat models.
- The study showed that dapagliflozin significantly improved kidney function by regulating AKI markers and reducing inflammation and oxidative stress, even in non-diabetic subjects.
- These findings suggest potential therapeutic benefits of dapagliflozin beyond its glucose-lowering effects, particularly in preventing kidney damage related to sepsis.
Prognostic factors for hospitalization for severe hypoglycemia without diabetes mellitus: a retrospective study.
Diabetol Int
October 2024
Department of Diabetes and Endocrinology, Yokohama City Minato Red Cross Hospital, Yokohama, Kanagawa Japan.
Patients with non-diabetic hypoglycemia have a poorer prognosis than those with diabetic hypoglycemia. However, the factors associated with prognosis remain unclear. Therefore, this study aimed to identify the prognostic factors for non-diabetic hypoglycemia.
View Article and Find Full Text PDFMyxedema Coma as a Presentation of Panhypopituitarism Secondary to Traumatic Brain Injury.
Case Rep Endocrinol
October 2024
Department of Endocrinology and Nutrition, Central University Hospital of Asturias/University of Oviedo, Oviedo, Spain.
Article Synopsis
- Myxedema coma often involves reduced consciousness and low body temperature, potentially linked to thyroid issues, especially in patients with head trauma and central hormone deficiencies.
- A 52-year-old man with head trauma exhibited symptoms like drowsiness and hypotension, with initial tests showing normal TSH levels but low ACTH and FT4, and his condition worsened before improving with medication.
- The case highlights the importance of assessing both TSH and FT4 levels for diagnosing central hypothyroidism, as relying solely on TSH might lead to overlooked conditions in patients showing hormone deficiency symptoms post-trauma.
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