In this paper, we present a new differential CMOS capacitive sensor for Lab-on-Chip applications. The proposed integrated sensor features a DC-input ΣΔ capacitance to digital converter (CDC) and two reference and sensing microelectrodes integrated on the top most metal layer in 0.35 μm CMOS process. Herein, we describe a readout circuitry with a programmable clocking strategy using a Charge Based Capacitance Measurement technique. The simulation and experimental results demonstrate a high capacitive dynamic range of 100 fF-110 fF, the sensitivity of 350 mV/fF and the minimum detectable capacitance variation of as low as 10 aF. We also demonstrate and discuss the use of this device for environmental applications through various chemical solvents.
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http://dx.doi.org/10.1109/TBCAS.2014.2336596 | DOI Listing |
Epithelial tissues in vitro undergo dynamic changes while differentiating heterogeneously on the culture substrate. This gives rise to diverse cellular arrangements which are undistinguished by conventional analysis approaches, such as transepithelial electrical resistance measurement or permeability assays. In this context, solid substrate-based systems with integrated electrodes and electrochemical impedance monitoring capability can address the limited spatiotemporal resolution of traditional porous membrane-based methods.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Electronics Technology Department, University of Madrid Carlos III, 28911 Leganes, Spain.
This paper explores the implementation of a VCO-based ADC, achieving an ENOB of 12 bits with 1 MHz of a sampling rate in the audio bandwidth. The solution exploits the scalability and PVT invariance of a novel digital-to-frequency converter to reduce the size and consumed power. The architecture has been validated in a 130 nm CMOS technology node displaying a power consumption of 105.
View Article and Find Full Text PDFImmunopharmacol Immunotoxicol
February 2025
Cancer Research Lab, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune, India.
Objective: Triple-Negative Breast Cancer (TNBC), the most challenging subtype of Breast Cancer (BC), currently lacks targeted therapy, presenting a significant therapeutic gap in its management. Tumor Associated Macrophages (TAMs) play a significant role in TNBC progression and could be targeted by repolarizing them from M2 to M1 phenotype. Matairesinol (MAT), a plant lignan, has been shown to exhibit anticancer, anti-inflammatory and immunomodulatory activities.
View Article and Find Full Text PDFNanomaterials (Basel)
November 2024
Department of Electronics Engineering, Chungnam National University, Daejeon 34134, Republic of Korea.
This paper introduces a Ku-band fully differential low-power high-input 1 dB compression point (P1dB) low-noise amplifier (LNA). A fully differential structure is employed to enhance the input P1dB, common-mode noise rejection, and second harmonic cancellation. The first stage adopts large transistors and is optimized for power consumption and noise figure (NF).
View Article and Find Full Text PDFPLoS One
November 2024
School of Electronics Engineering, VIT-AP University, Vijayawada, India.
This paper presents a design of fully differential chopper amplifier employing the flipped voltage follower (FVF) adaptive biasing technique, focusing on its potential use in biopotential recording applications. The suggested architectural OTA incorporates self-cascoded current mirrors (SCCMs) as the active load to achieve a substantial output swing. The FVFs based adaptive biasing approach for the differential input stage boosts extra current and enhances gain and dynamic characteristics.
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