Development of a fluoride chronic effects benchmark for aquatic life in freshwater.

Environ Toxicol Chem

Golder Associates, Burnaby, British Columbia, Canada.

Published: November 2014

AI Article Synopsis

  • Canada has outdated interim water-quality guidelines for fluoride, with a 2002 guideline for protecting freshwater aquatic life and a 1995 guideline in one province.
  • The US lacks a national benchmark for fluoride in freshwater; only one state has established a guideline.
  • The study reviewed data on fluoride toxicity, finding acute toxicity levels between 11.5 and over 800 mg/L and chronic effects starting as low as 1.8 mg/L, leading to a derived chronic effects benchmark of 1.94 mg/L using a species sensitivity distribution approach.

Article Abstract

Canada has an interim water-quality guideline for fluoride for protection of freshwater aquatic life that dates from 2002, and 1 Canadian province has a different interim water-quality guideline for fluoride that dates to 1995. The United States does not have a national benchmark for fluoride in freshwater, and only 1 US state has such a benchmark. There are no other national or regional benchmarks for fluoride chronic toxicity in freshwater. In the present study, available data on the acute and chronic toxicity of fluoride to freshwater aquatic life were compiled and reviewed. Acute toxicity was reported to occur at concentrations ranging from 11.5 to >800 mg/L fluoride (F(-) ). The majority of chronic effects occur at concentrations between 1.8 mg/L and 195 mg/L. A total of 10 chronic studies representing 16 species (5 fish, 7 invertebrates, and 4 algae/aquatic plants) were used to derive a chronic effects benchmark of 1.94 mg/L F(-) , applying the species sensitivity distribution approach.

Download full-text PDF

Source
http://dx.doi.org/10.1002/etc.2724DOI Listing

Publication Analysis

Top Keywords

chronic effects
12
aquatic life
12
fluoride chronic
8
effects benchmark
8
interim water-quality
8
water-quality guideline
8
guideline fluoride
8
freshwater aquatic
8
fluoride freshwater
8
chronic toxicity
8

Similar Publications

Hepatitis B virus hijacks MRE11-RAD50-NBS1 complex to form its minichromosome.

PLoS Pathog

January 2025

State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Medical School, Wuhan University, Wuhan, China.

Chronic hepatitis B virus (HBV) infection can significantly increase the incidence of cirrhosis and liver cancer, and there is no curative treatment. The persistence of HBV covalently closed circular DNA (cccDNA) is the major obstacle of antiviral treatments. cccDNA is formed through repairing viral partially double-stranded relaxed circular DNA (rcDNA) by varies host factors.

View Article and Find Full Text PDF

The BMT CTN 1703 phase III trial confirmed that graft-versus-host disease (GVHD) prophylaxis with post-transplantation cyclophosphamide (PTCy), tacrolimus (Tac), and mycophenolate mofetil (MMF) results in superior GVHD-free, relapse-free survival (GRFS) compared with Tac/methotrexate (MTX) prophylaxis. This companion study assesses the effect of these regimens on patient-reported outcomes (PROs). Using the Lee Chronic GVHD Symptom Score and PROMIS subscales (physical function, GI symptoms, social role satisfaction) as primary end points and hemorrhagic cystitis symptoms and Lee subscales as secondary end points, responses from English and Spanish speakers were analyzed at baseline and days 100, 180, and 365 after transplant.

View Article and Find Full Text PDF

Tracheal mucosal keratosis: Case discussion and literature review.

Chron Respir Dis

January 2025

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

A 57-year-old female presented with a chief complaint of cough, with productive yellow sputum particularly severe in the morning. Bronchoscopy revealed inflammatory changes in both main bronchi, with abundant white purulent secretions and necrotic material adhering to the luminal surface. Histopathological examination showed chronic inflammatory changes in the mucosal tissue, with mild hyperplasia of the local squamous epithelium and evidence of keratinization in the surrounding area, consistent with a diagnosis of tracheal mucosal keratosis.

View Article and Find Full Text PDF

Anti-Estrogen Therapy Achieves Complete Remission and Stability in Recurrent Cervical Cancer: A Case Study.

Am J Case Rep

January 2025

Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

BACKGROUND Studies using transgenic mouse models have demonstrated that estrogen is necessary for the development of cervical cancer, particularly in tissues responsive to estrogen. Estrogen also protects cervical cancer cells from apoptosis, suggesting its role in the survival and persistence of cancer cells. CASE REPORT An 84-year-old woman with diabetes mellitus, hypertension, and stage III chronic renal failure was diagnosed with cervical squamous cell carcinoma, FIGO stage IB2.

View Article and Find Full Text PDF

Implantable systems with chronic stability, high sensing performance, and extensive spatial-temporal resolution are a growing focus for monitoring and treating several diseases such as epilepsy, Parkinson's disease, chronic pain, and cardiac arrhythmias. These systems demand exceptional bendability, scalable size, durable electrode materials, and well-encapsulated metal interconnects. However, existing chronic implantable bioelectronic systems largely rely on materials prone to corrosion in biofluids, such as silicon nanomembranes or metals.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!