AI Article Synopsis
- Developed a UV exposure protocol that effectively inactivates Toxoplasma gondii tachyzoites in just 1 minute.
- This treatment halted both parasite replication and cyst formation in laboratory settings as well as in mice, while still allowing for a strong IgG immune response.
- The protocol could be utilized to explore how the immune response affects changes in rodent behavior after T. gondii infection.
Article Abstract
We developed a protocol to inactivate Toxoplasma gondii (T. gondii) tachyzoites employing 1 min of ultraviolet (UV) exposure. We show that this treatment completely inhibited parasite replication and cyst formation in vitro and in vivo but did not affect the induction of a robust IgG response in mice. We propose that our protocol can be used to study the contribution of the humoral immune response to rodent behavioral alterations following T. gondii infection.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435842 | PMC |
| http://dx.doi.org/10.1016/j.exppara.2014.08.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
3D Scanning of Wood-Plastic Composite Decking After Cyclic Thermal Action.
Materials (Basel)
December 2024
Instytut Techniki Budowlanej, 00-611 Warsaw, Poland.
Wood-plastic composites (WPC) combine the properties of polymers and wood, providing an attractive alternative to traditional materials, particularly for terrace flooring. When exposed to various environmental conditions, WPCs are affected by factors, such as water and ultraviolet (UV) radiation. Although most test methods for assessing the durability of these products have focused on changes in mechanical properties and linear dimensions, out-of-plane deformations (concavity and convexity) are often overlooked.
View Article and Find Full Text PDFEffect of Extensive Solar Ultra-Violet Irradiation on the Durability of High-Density Polyethylene- and Polypropylene-Based Wood-Plastic Composites.
Polymers (Basel)
December 2024
Dhahran Techno-Valley, King Fahd University of Petroleum & Minerals, Dhahran 31261, Saudi Arabia.
The natural and laboratory-accelerated weathering of wood-plastic composites (WPCs) based on high-density polyethylene (HDPE) and polypropylene (PP) plastics was investigated in this study. Injection molded samples of WPCs with different loadings of wood fiber ranging from 0 to 36 wt.% of wood were subjected to laboratory-accelerated weathering and natural weathering.
View Article and Find Full Text PDFMulti-Omics Research Reveals the Effects of the ABA-Regulated Phenylpropanoid Biosynthesis Pathway on the UV-B Response in Pall.
Plants (Basel)
January 2025
Jilin Provincial Key Laboratory of Plant Resource Science and Green Production, Jilin Normal University, Siping 136000, China.
The growing depletion of the ozone layer has led to increased ultraviolet B (UV-B) radiation, prompting plants like the alpine Pall. () to adapt to these harsh conditions. This study explored how abscisic acid (ABA) signaling influences 's metabolic responses under UV-B stress.
View Article and Find Full Text PDFIncreasing temperature counteracts the negative effects of ultraviolet radiation on Microcystis aeruginosa under future climate scenarios in relation to physiological processes.
Comp Biochem Physiol C Toxicol Pharmacol
January 2025
Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina, CABA, Argentina; Departamento de Radiobiología, Centro Atómico Constituyentes, Comisión Nacional de Energía Atómica, General San Martín, Argentina; Red de Investigación de estresores Marinos-Costeros en América Latina y el Caribe, Mar del Plata, Argentina. Electronic address:
Heat waves, are a major concern related to climate change, and are projected to increase in frequency and severity. This temperature rise causes thermal stratification, exposing surface-dwelling organisms to higher levels of ultraviolet radiation (UVR). This study aims to understand how the toxic bloom-forming cyanobacterium Microcystis aeruginosa adapts to changing climatic conditions.
View Article and Find Full Text PDFNon-Genetic Biomarkers in Merkel Cell Carcinoma: Prognostic Implications and Predictive Utility for Response to Anti-PD-(L)1 Immune Checkpoint Inhibitors.
Exp Dermatol
January 2025
Department of Medicine and Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Merkel cell carcinoma (MCC) is a skin cancer that arises due to either Merkel cell polyomavirus infection (MCPyV) or ultraviolet (UV) radiation exposure, presenting primarily in the head and neck region of fair-skinned males. The recent success of PD-(L)1 immune checkpoint inhibitors (ICIs) in locally advanced/metastatic MCC, with an objective response rate (ORR) around 50% and improved survival, as a first-line treatment has moved ICIs to the forefront of therapy for MCC and generated interest in identifying biomarkers to predict clinical response. The MCC tumour microenvironment (TME) contains various components of the adaptive and innate immune system.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!