AI Article Synopsis
- DN TCRαβ(+) intraepithelial T cells are a unique group of T cells that have been largely ignored in immune response studies.
- Their development is influenced by the specificity of their T cell receptors (TCRs), and they exhibit a diverse and distinct type of MHC restriction, differing from traditional CD4(+) and CD8αβ(+) T cells.
- These findings suggest that DN TCRαβ(+) T cells represent a third lineage of T lymphocytes with their own specific immune roles.
Article Abstract
Coreceptor CD4 and CD8αβ double-negative (DN) TCRαβ(+) intraepithelial T cells, although numerous, have been greatly overlooked and their contribution to the immune response is not known. Here we used T cell receptor (TCR) sequencing of single cells combined with retrogenic expression of TCRs to study the fate and the major histocompatibility complex (MHC) restriction of DN TCRαβ(+) intraepithelial T cells. The data show that commitment of thymic precursors to the DN TCRαβ(+) lineage is imprinted by their TCR specificity. Moreover, the TCRs they express display a diverse and unusual pattern of MHC restriction that is nonoverlapping with that of CD4(+) or CD8αβ(+) T cells, indicating that they sense antigens that are not recognized by the conventional T cell subsets. The new insights indicate that DN TCRαβ(+) T cells form a third lineage of TCRαβ T lymphocytes expressing a variable TCR repertoire, which serve nonredundant immune functions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142827 | PMC |
| http://dx.doi.org/10.1016/j.immuni.2014.07.010 | DOI Listing |
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