Feeding states may affect the performance of colonic prodrugs. The aim is to investigate the influence of feeding regimen in Wistar rats on: (i) distribution and pH contents along the gut and (ii) metabolism of two colonic prodrugs, diclofenac-β-cyclodextrin and a commercially available control, sulfasalazine, within the caecal and colonic contents. Male Wistar rats were subject to four different feeding regimens, the gut contents characterized (mass and pH) and the metabolism of prodrugs investigated. The feeding regimen affects gut contents (mass and pH), more specifically in the stomach and lower intestine, and affects the rate of metabolism of diclofenac-β-cyclodextrin, but not that of sulfasalazine. The latter's degradation is much faster than that of diclofenac-β-cyclodextrin while the metabolism of both prodrugs is faster in colonic (versus caecal) contents. Fasting results in most rapid degradation of diclofenac-β-cyclodextrin, possibly due to lack of competition (absence of food) for microbial enzymatic activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.carbpol.2014.06.064 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Towards developing a "baby translator" - an exploration of how infant appetite cues are understood.
Appetite
January 2025
School of Psychology, University of Leeds, Leeds, LS2 9JT. Electronic address:
Caregivers' feeding practices shape their child's eating patterns and subsequent health. Research shows that sensitive feeding is linked to healthy development and self-regulation but depends on caregiver responsiveness to infant needs and appetite cues. Responsive feeding (RF) is influenced both by characteristics of the caregiver and expressiveness of the infant.
View Article and Find Full Text PDFIntermittent fasting and neurocognitive disorders: What the evidence shows.
J Nutr Health Aging
January 2025
St. Louis University Department of Psychiatry and Behavioral Neuroscience, Monteleone Hall, 1438 South Grand Boulevard, St. Louis, MO 63104, United States.
Introduction: Intermittent fasting (IF) has emerged as a potential lifestyle intervention for mitigating cognitive decline and enhancing brain health in individuals with mild to major neurocognitive disorders. Unlike preventive strategies, this review evaluates IF as a therapeutic approach, focusing on its effects on neuroplasticity, inflammation, and cognitive function.
Methods: A narrative review was conducted using a comprehensive PubMed search with the terms "intermittent fasting AND neurocognition" and "intermittent fasting AND neuroplasticity".
To detox or not to detox? The impact of different approaches to social media detox strategies on body image and wellbeing.
Body Image
January 2025
School of Applied Psychology, Griffith University, Australia.
This study compared the efficacy of three 7-day detox strategies on young women's body image and wellbeing. The three strategies were: (a) Insta/TikTok break, (b) daily time-cap (30 minutes max), and (c) Insta/TikTok cleanse (removing appearance-focused content from feeds). A sample of 175 women aged 17-35 (M = 22.
View Article and Find Full Text PDFUnlocking the phosphorus circularity potential of corn belt watersheds with biorefinery phosphorus recovery incentives.
J Environ Manage
January 2025
Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. Electronic address:
As global phosphorus (P) stores rapidly decline, P fed algal blooms continue to threaten critical freshwater resources across the globe. In the Midwestern United States (US), particularly the Corn Belt, biorefineries could play a key role in addressing this issue. By recovering P from the byproducts of ethanol production these facilities could reduce the P content of distillers grain feed, thereby reducing P excreted in manures.
View Article and Find Full Text PDFNano-TiO impairs the health of crabs Charybdis japonica under warming conditions through waterborne and dietary exposures.
J Hazard Mater
January 2025
International Research Center for Marine Biosciences, Shanghai Ocean University, Ministry of Science and Technology, College of Fisheries and Life Science, Shanghai 201306, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai 201306, China. Electronic address:
The widespread use of nano titanium dioxide (nano-TiO₂) poses ecological risks to marine ecosystems, especially when combined with ocean warming. However, most previous studies have only examined water-related exposures, leaving a gap in research on the impact of food transfer on organisms. In this work, the harmful impacts of nano-TiO on the Japanese swimming crab Charybdis japonica were studied through three scenarios: direct exposure (DE) of the crabs to warming and nano-TiO, indirect exposure (IE) via consumption of thick-shelled mussels Mytilus coruscus exposed to the same conditions, and combined exposure (CE), where crabs were directly subjected to warming and nano-TiO while feeding affected mussels.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!