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Reasons for retraction of clinical research articles in PubMed indexed medical journals from 2012 to 2022.
Indian J Med Ethics
January 2025
Department of Clinical Pharmacology, Toipwala National Medical College and BYL Nair Charitable Hospital, Mumbai 400008, Maharashtra, INDIA.
Background: Misconduct in the publication of research articles is a serious concern for the scientific community. This study was conducted with the objective to assess various reasons for retraction of clinical research articles published in PubMed indexed journals from all over the world since 2012 to 2022.
Methods: A search was performed on the PubMed database for retracted research articles using filters for "retracted publication".
The DREAM BIG project as a model for harmonizing early measures of parental care and parent-child interactions across epidemiological cohorts.
Front Child Adolesc Psychiatry
October 2023
Lady Davis Institute, The Jewish General Hospital, Montreal, QC, Canada.
Parenting is a key contributor to child development. The effects of parenting, however, also depend on child characteristics, including genetic factors. A more complete appraisal of the role of parenting thus requires a comprehensive developmental model which explores questions about parenting behavior, child susceptibility to parenting, and child psychopathology.
View Article and Find Full Text PDFLatest Advancements in Transcutaneous Electrical Nerve Stimulation (TENS) and Electronic Muscle Stimulation (EMS): Revisiting an Established Therapy with New Possibilities.
J Pain Res
January 2025
NXTSTIM INC. Department of Pain Medicine, San Diego, CA, USA.
Transcutaneous Electrical Nerve Stimulation (TENS) and Electronic Muscle Stimulation (EMS) are non-invasive therapies widely used for pain relief and neuromuscular adaptation. However, the clinical research supporting the efficacy of TENS in chronic pain management is limited by significant methodological flaws, including small sample sizes and inconsistent reporting of stimulation parameters. TENS modulates pain perception through various techniques, targeting specific nerve fibers and pain pathways.
View Article and Find Full Text PDFIntegrating epigenetic modification and stem cell therapy strategies: A novel approach for advancing Alzheimer's disease treatment - A literature review.
Narra J
December 2024
Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Alzheimer's disease (AD) is the most frequent form of dementia and represents an increasing global burden, particularly in countries like Indonesia, where the population has begun to age significantly. Current medications, including cholinesterase inhibitors and NMDA receptor antagonists, have modest effects on clinical symptoms in the early to middle stages, but there is no curative treatment available so far despite progress. Activating or repressing epigenetic modifications, including DNA methylation, histone modification and microRNA regulation, appears to play an important role in AD development.
View Article and Find Full Text PDFCombining theory and usability testing to inform optimization and implementation of an online primary care depression management tool.
BMC Med Inform Decis Mak
January 2025
Department of Psychiatry, University of Ottawa, Ottawa, Canada.
Background: The 'Ottawa Depression Algorithm' is an evidence-based online tool developed to support primary care professionals care for adults with depression. Uptake of such tools require provider behaviour change. Identifying issues which may impact use of an innovation in routine practice (i.
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