Dermal elastic fibres in biopsies taken from sun-exposed involved digital skin and sun-protected uninvolved skin on the medial aspect of the upper arms from 13 patients with systemic sclerosis were examined by light and transmission electron microscopy. For controls, biopsies were taken from similar sites from 4 age- and sex-matched healthy volunteers and 4 patients with primary Raynaud's phenomenon. On light microscopy only the control digital biopsies showed mild actinic changes of the elastic fibres whereas in all the biopsies from patients with systemic sclerosis identical changes of thickening, clumping and fragmentation of the elastic fibres were observed. Quantitative assessment of the dermal elastic fibres using microdensitometry and video image analysis showed no significant difference between the patients and controls. On electron microscopy more advanced abnormalities similar to those seen in actinic damage and chronological aging were found in the biopsies from all the patients with systemic sclerosis compared to the controls.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF01606315 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ear pinna growth and differentiation is conserved in murids and requires BMP signaling for chondrocyte proliferation.
Development
January 2025
Department of Biology, University of Kentucky, Lexington, KY 40506, USA.
Despite being a major target of reconstructive surgery, development of the ear pinna remains poorly studied. Here we provide a cellular characterization of late gestational and postnatal ear pinna development in two rodents and investigate the role of BMP5 in expansion and differentiation of auricular elastic cartilage. We find that ear pinna development is largely conserved between Mus musculus and the highly regenerative Acomys dimidiatus.
View Article and Find Full Text PDFTendon-mimicking anisotropic alginate-based double-network composite hydrogels with enhanced mechanical properties and high impact absorption.
Carbohydr Polym
March 2025
School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea; Department of MetaBioHealth, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea; Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea; Institute of Quantum Biophysics (IQB), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea. Electronic address:
Tendons are anisotropic tissues with exceptional mechanical properties, which result from their unique anisotropic structure and mechanical behavior under stress. While research has focused on replicating anisotropic structures and mechanical properties of tendons, fewer studies have examined their specific mechanical behaviors. Here, we present a simple method for creating calcium-crosslinked alginate-based double-network hydrogels that mimics tendons by exhibiting anisotropic structure, high mechanical strength and toughness, and a distinctive "toe region" when stretched.
View Article and Find Full Text PDFBi-ventricular elastic material parameters estimation using 3D CMR myocardial strains in rheumatic heart disease patients.
J Biomech
January 2025
Division of Cardiology, Department of Medicine, University of Cape Town, Cape Town, South Africa; Cape Universities Body Imaging Centre, Faculty of Health Sciences, University of Cape Town, South Africa; South African Medical Research Council Extramural Unit on Intersection of Noncommunicable Diseases and Infectious Diseases. Electronic address:
Understanding the elastic material behavior of myocardium during the diastolic phase is critical for evaluating cardiac function and improving treatments for diastolic abnormalities. This study introduces a novel multi-objective optimization framework that incorporates both strain and volume measurements to enhance the accuracy of myocardial property assessments in Rheumatic Heart Disease (RHD) patients and healthy controls. By employing global volume and strain measurements instead of segmented strains from the sixteen AHA regions, we achieve a robust alignment with the Klotz curve across all groups, indicating an accurate simulation of end-diastolic pressure-volume relationships (EDPVRs).
View Article and Find Full Text PDFEffects of a supercritical CO process on the mechanical properties and microarchitecture of trabecular bone using compression testing and microcomputed tomography.
J Mech Behav Biomed Mater
January 2025
Aix Marseille Univ, CNRS, ISM, 13009, Marseille, France; Aix Marseille Univ, APHM, CNRS, ISM, Sainte-Marguerite Hospital, Institute for Locomotion, Department of Orthopaedics and Traumatology, 13009, Marseille, France.
Surgeons frequently use allograft bone due to its osteoconductive, osteoinductive, and osteogenic properties. Preservation processes are employed to clean the allograft, improve its conservation, and ensure its sterilization. Many current processes use the properties of supercritical CO to remove bone marrow.
View Article and Find Full Text PDFPeptide platform for 3D-printed Ti implants with synergistic antibacterial and osteogenic functions to enhance osseointegration.
Mater Today Bio
February 2025
Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, Shanxi, China.
Bone defects caused by trauma, infection, or tumors present a major clinical challenge. Titanium (Ti) implants are widely used due to their excellent mechanical properties and biocompatibility; however, their high elastic modulus, low surface bioactivity, and susceptibility to infection hinder osseointegration and increase failure rates. There is an increasing demand for implants that can resist bacterial infection while promoting osseointegration.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!