Background: Clostridum difficile is a gram-positive, spore-forming anaerobic bacillus that has substantial associated morbidity, mortality, and associated healthcare burdens. Clostridium difficile spores are not destroyed by alcohol. Alcohol gel dispensers are used commonly as the hand sanitization method of choice in hospitals. It is possible that gel dispensers are fomites for C. difficile.
Methods: Thirty alcohol-based gel dispenser handles outside of rooms of patients with active C. difficile infection were sampled. The samples were assessed for C. difficile by both culture and polymerase chain reaction (PCR). The samples were also assessed for other organisms by culture.
Results: No C. difficile was cultured or detected by PCR on any of the gel dispensers. Coagulase-negative Staphyloccus spp., diptheroids, and Bacillus spp. were the organisms detected most commonly.
Conclusion: At our institution, C. difficile is not present on alcohol-based gel dispensers, but other potentially pathogenis are.
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http://dx.doi.org/10.1089/sur.2013.102 | DOI Listing |
Pharmaceutics
November 2024
Faculty of Medicine, Institute of Pharmacy, University of Tartu, Nooruse 1, 50411 Tartu, Estonia.
: An automated extrusion-based material deposition is a contemporary and rapid method for pharmaceutical dose-dispensing and preparing (printing) individualized solid dosage forms. The aim of this study was to investigate and gain knowledge of the feasibility of automated extrusion-based material deposition technology in preparing customized prednisolone (PRD)-loaded gel tablets for veterinary applications (primarily for dogs and cats). : The PRD loads of the extrusion-based deposited gel tablets were 0.
View Article and Find Full Text PDFAnal Biochem
February 2025
Laboratory for Optics and Applied Mechanics, Department of Mechanical & Aerospace Engineering, Monash University, Clayton, Victoria, 3800, Australia. Electronic address:
In gel electrophoresis, samples that are dispensed too high above or too low into the wells result in sub-optimal outcomes. Here, an adapted 3D printer liquid handler equipped with an optical sensor was found to attain vertical sample delivery positionings at a standard deviation over mean ratio of 0.008.
View Article and Find Full Text PDFEur J Pharm Sci
January 2025
Pharmaceutical Sciences Laboratory, Science and Engineering, Åbo Akademi University, BioCity, Tykistökatu 6A, Turku FI-20520, Finland; CurifyLabs Oy, Salmisaarenaukio 1, Helsinki FI-00180, Finland.
The exploration of three-dimensional (3D) printing inspired technologies in pharmaceutical compounding reveals a promising frontier in personalized medicine manufacture. This study focuses on the development of clopidogrel bisulphate tablets, with doses ranging from 2 mg to 20 mg per tablet, suitable for pediatric use. The study explored a semi-solid extrusion-based deposition technology already being used in compounding pharmacies across several European locations.
View Article and Find Full Text PDFTalanta
February 2025
China Light Industry Key Laboratory of Food Intelligent Detection & Processing, School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China; International Joint Research Laboratory of Intelligent Agriculture and Agri-products Processing, Jiangsu University, Zhenjiang 212013, China.
The rapid in situ detection of pesticide residues in real samples based on surface-enhanced Raman spectroscopy (SERS) remains a challenge, necessitating an urgent need for a feasible solution that addresses issues such as sample complexity, reproducibility, and SERS substrate stability. This paper proposes a flexible SERS substrate, which consists of a composite gel made of sodium alginate-chitosan loaded with silver nanocubes (SA-CTS@AgNCs). The flexible nature of the SERS substrate enables the analysis of irregular surfaces of apples, dispensing with laborious pretreatment and promoting an effective contact with target molecules.
View Article and Find Full Text PDFAnesth Analg
August 2024
From the Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee.
Background: The majority of opioid analgesics prescribed for pain after ambulatory pediatric surgery remain unused. Most parents do not dispose of these leftover opioids or dispose of them in an unsafe manner. We aimed to evaluate the association of optimal opioid disposal with a multidisciplinary quality improvement (QI) initiative that proactively educated parents about the importance of optimal opioid disposal practices and provided a home opioid disposal kit before discharge after pediatric ambulatory surgery.
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