AI Article Synopsis

  • Cervical cancer is a prevalent and rising issue among females, prompting urgent needs for new anticancer drugs.
  • A newly discovered compound, LG003, showed strong anticancer effects against the SiHa cervical cancer cell line, outperforming several standard treatments.
  • LG003's effectiveness is dependent on time and dose, and it induces cell death by causing apoptosis and damaging cell membranes through a physiological pathway, indicating its potential as a cervical cancer therapy.

Article Abstract

Cervical cancer is one the most common malignancies among females. In recent years, its incidence rate has shown a rising trend in some countries so that development of anticancer drugs for cervical cancer is an urgent priority. In our recent anticancer drug discovery screen, 1, 2-di (quinazolin-4-yl)diselane (LG003) was found to possess wide spectrum anticancer efficacy. In the present work, the in vitro anticancer activity of LG003 was evaluated in the SiHa cervical cancer cell line. Compared with commercial anticancer drugs 10-hydroxycamptothecin, epirubicin hydrochloride, taxol and oxaliplatin, LG003 showed better anticancer activity. Furthermore, inhibition effects were time- and dose-dependent. Morphological observation exhibited LG003 treatment results in apoptosis like shrinking and blebbing, and cell membrane damage. Lactate dehydrogenase release assay revealed that LG003 exerts such effects in SiHa cells through a physiology pathway rather than cytotoxicity, which suggests that title compound LG003 can be a potential candidate agent for cervical cancer.

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http://dx.doi.org/10.7314/apjcp.2014.15.15.6301DOI Listing

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