AI Article Synopsis
- PPPDE1 is a protein found to be less present in pancreatic cancer tissues compared to normal tissues, indicating a potential role in tumor suppression.
- In a study analyzing 96 cancer and 31 normal tissue samples, lower levels of PPPDE1 were associated with reduced membrane expression of plakoglobin and an increased tendency for β-catenin to enter the nucleus in cancer cells.
- These findings suggest a connection between PPPDE1 expression and the behavior of key proteins involved in cell signaling and adhesion, which could impact the progression of pancreatic ductal adenocarcinoma.
Article Abstract
Human PPPDE peptidase domain-containing protein 1 (PPPDE1) is a recently identified protein; however, its exact functions remain unclear. In our previous study, the PPPDE1 protein was found to be decreased in certain cancer tissues. In the present study, a total of 96 pancreatic ductal carcinoma tissue samples and 31 normal tissues samples were assessed to investigate the distribution of plakoglobin and β-catenin under the conditions of various PPPDE1 expression levels by means of immunohistochemistry. Generally, the staining of PPPDE1 was strong in normal tissues, but weak in cancer tissues. Plakoglobin was mainly distributed along the membrane and cytoplasm border in normal cells, but was less evident in the membranes of cancer cells. In particular, a greater percentage of cells exhibited low membrane plakoglobin expression in cancer tissue with low PPPDE1 expression (PPPDE1-low cancer) compared with that in cancer tissue with high PPPDE1 expression (PPPDE1-high cancer). The distribution of β-catenin in normal tissues was similar to that of plakoglobin. However, β-catenin was peculiarly prone to invade nucleus in PPPDE1-low cancer compared with PPPDE1-high cancer. Our data suggested potential links between PPPDE1 expression and the distribution of plakoglobin and β-catenin in pancreatic ductal adenocarcinoma, providing insights into the role of PPPDE1 in the progression of pancreatic cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114641 | PMC |
| http://dx.doi.org/10.3892/ol.2014.2279 | DOI Listing |
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Article Synopsis
- PPPDE1 is a protein found to be less present in pancreatic cancer tissues compared to normal tissues, indicating a potential role in tumor suppression.
- In a study analyzing 96 cancer and 31 normal tissue samples, lower levels of PPPDE1 were associated with reduced membrane expression of plakoglobin and an increased tendency for β-catenin to enter the nucleus in cancer cells.
- These findings suggest a connection between PPPDE1 expression and the behavior of key proteins involved in cell signaling and adhesion, which could impact the progression of pancreatic ductal adenocarcinoma.
Comprehensive analysis of expression profile reveals the ubiquitous distribution of PPPDE peptidase domain 1, a Golgi apparatus component, and its implications in clinical cancer.
Biochimie
July 2013
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, No. 1, Keyuan Road 4, Gaopeng Street, Chengdu 610041, China.
PPPDE peptidase domain 1 (PPPDE1) is a recently identified gene; however, its expression regulation and biological function are unclear. Previous studies have indicated that PPPDE1 is involved in embryogenesis, apoptosis induction and cell cycle regulation. In the present study, we first used an anti-PPPDE1 antibody to determine that endogenous PPPDE1 is located in the Golgi apparatus.
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