AI Article Synopsis
- PTEN is a crucial tumor suppressor that influences cell functions, and its specific role in squamous cell carcinoma (SCC) of the tongue is not fully understood.
- The study established a cell line to examine how PTEN affects SCC-4 cell proliferation, invasion, and apoptosis, finding that it induces cell death through the inhibition of a certain signaling pathway.
- PTEN also regulates the epithelial-mesenchymal transition, enhancing E-cadherin (which hampers invasion) while reducing proteins like vimentin and SNAIL, thus providing insights into its role in tongue carcinoma progression and metastasis.
Article Abstract
Phosphatase and tensin homolog (PTEN) is a potent tumor suppressor which regulates various cellular functions. The aim of the present study was to analyze the function of gene expression in squamous cell carcinoma (SCC) cells. This gene exhibits a unique function in cell migration and proliferation during the early stages of embryonic development. However, its role as a tumor suppressor gene in tongue squamous carcinoma cells remains unclear. In the present study, an SCC-4 cell line stably expressing was established and the effects of gene expression on SCC-4 cell proliferation, invasion and apoptosis were investigated. expression was found to induce apoptosis in SCC-4 cells, possibly via negative regulation of the phosphatidylinositide 3-kinase/Akt signaling pathway and increased expression of Bcl-2-interacting mediator of cell death. In addition, PTEN was found to control the epithelial-mesenchymal transition in SCC cells, thereby reducing their invasive ability. Furthermore, Transwell assay revealed that the expression of E-cadherin was increased, while the expression of vimentin and SNAIL was decreased. This study has provided an important insight into the mechanisms by which PTEN mediates the progression and early metastasis of tongue carcinoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114615 | PMC |
| http://dx.doi.org/10.3892/ol.2014.2283 | DOI Listing |
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