AI Article Synopsis
- - Mutations in the FGFR3 gene are linked to six skeletal dysplasia conditions, including achondroplasia and thanatophoric dysplasia, each having unique clinical and radiographic features.
- - These disorders vary in severity, with conditions like hypochondroplasia being milder and thanatophoric dysplasia being lethal.
- - The reported patient has a specific FGFR3 mutation (Lys650Met) typically associated with SADDAN but also shares characteristics of thanatophoric dysplasia, highlighting complexities in the presentation of these conditions.
Article Abstract
Mutations in the fibroblast growth factor receptor 3 (FGFR3) gene account for six related skeletal dysplasia conditions: achondroplasia, hypochondroplasia, thanatophoric dysplasia types 1 and 2, SADDAN (severe achondroplasia with developmental delay and acanthosis nigricans), and platyspondylic lethal skeletal dysplasia, San Diego type. This group of disorders has very characteristic clinical and radiologic features, which distinguish them from other skeletal dysplasias. They display a spectrum of severity in the skeletal findings, ranging from relatively mild hypochondroplasia to lethal thanatophoric dysplasia. We report a patient who has the missense FGFR3 mutation, Lys650Met, previously reported in association only with SADDAN, who exhibits some findings similar to both thanatophoric dysplasia (types 1 and 2) in addition to those findings characteristic of SADDAN.
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| http://dx.doi.org/10.1007/s00256-014-1983-6 | DOI Listing |
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