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Gastro-oesophageal reflux in children.
Scand J Gastroenterol Suppl
August 1997
Emma Children's Hospital AMC, Amsterdam, The Netherlands.
Gastro-oesophageal reflux in children is different in several aspects from in adults. Pathophysiologically, 50% of reflux episodes are due to increased abdominal pressure which overcomes the lower oesophageal sphincter pressure. This pathophysiological abnormality disappears in children at the age of 1.
View Article and Find Full Text PDFA comparison of gastro-oesophageal reflux in volunteers assessed by ambulatory pH and gamma monitoring after treatment with either Liquid Gaviscon or Algicon Suspension.
Aliment Pharmacol Ther
October 1992
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, UK.
This study was designed to compare the effectiveness of single doses of either Liquid Gaviscon or Algicon Suspension in the suppression of food and acid reflux into the oesophagus after a test meal in volunteers. After the pH electrode and gamma detector were positioned 5 cm above the cardia, the volunteers received a refluxogenic radiolabelled meal. The subjects then remained untreated, or thirty minutes later they were given a dose of unlabelled Algicon Suspension, or Liquid Gaviscon and a recording was made for a minimum of 3 hours.
View Article and Find Full Text PDFIn-vivo anti-reflux and raft properties of alginates.
Aliment Pharmacol Ther
December 1990
Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia.
The comparative efficacy of two alginate-containing anti-reflux preparations (Gaviscon, Algicon) was assessed in a single blind crossover study of 20 patients with gastro-oesophageal reflux disease. The clinical efficacy study was preceded by two studies in healthy volunteers to assess the intragastric effects of Algicon and Gaviscon by pH measurement, endoscopic visualization and gamma scintigraphy. Algicon and Gaviscon were shown to form a raft in the fasting and fed human stomach, with Algicon alone having a potent antacid effect below and within the raft.
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