AI Article Synopsis
- New Delhi metallo-beta-lactamase (NDM-1) is an enzyme that can break down nearly all beta-lactam antibiotics except aztreonam, using zinc ions for activity.
- The study investigates how NDM-1 interacts with various carbapenem antibiotics through molecular docking techniques.
- Autodock4.2 software was used to analyze the interactions between NDM-1 and multiple carbapenems individually, helping to understand the effectiveness of these drugs against the enzyme.
Article Abstract
New Delhi metallo-beta-lactamase (NDM-1) is a beta-lactamase (class B carbapenemase) containing Zn and other divalent cations as cofactors which possesses the ability to inactivate all beta lactams (including carbapenems) except aztreonam by catalyzing the hydrolytic cleavage of the substrate amide bond. Carbapenemases are either serine enzymes or metallo-β-lactamases (MBLs) that utilize at least one zinc ion for hydrolysis. The present study describes the molecular interaction of carbapenems (Imipenem, Meropenem, Ertapenem, Doripenem, Panipenem, Biapenem, Razupenem, Faropenem, Tebipenem and Tomopenem) with NDM-1, β-lactamase enzyme. Docking between NDM-1 and each of these carbapenems (separately) was performed using 'Autodock4.2'.
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| http://dx.doi.org/10.1007/s12539-013-0027-6 | DOI Listing |
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Article Synopsis
- New Delhi metallo-beta-lactamase (NDM-1) is a type of enzyme that can inactivate most beta-lactam antibiotics, including carbapenems, except for aztreonam, by breaking down their molecular structure.
- The study focuses on how various carbapenems, including Imipenem and Meropenem, interact with the NDM-1 enzyme through a process called molecular docking.
- Researchers used Autodock4.2 software to analyze these interactions, aiming to understand the relationship between NDM-1 and different carbapenem antibiotics.
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