AI Article Synopsis
- A 5-year-old patient with tuberous sclerosis developed severe complex partial seizures, averaging 10-20 per day, with an EEG indicating a right frontal epileptogenic focus.
- A CT scan revealed calcifications in the right frontal area and neuropsychological tests showed a low verbal IQ of 69 and a moderate performance IQ of 88.
- After surgical removal of the identified epileptogenic tissue, the patient experienced a significant reduction in seizures, reporting only two brief episodes in the following year.
Article Abstract
A patient with tuberous sclerosis diagnosed at the age of 5 years developed an intractable seizure disorder characterized by complex partial seizures numbering 10-20/day. Interictal electroencephalograms (EEG) showed a right frontal epileptogenic focus. A computerized tomography scan demonstrated calcification in the right frontal region at two sites, periventricular calcification and multiple low density lesions. Neuropsychological assessment showed a verbal intelligence quotient (IQ) of 69 and a performance IQ of 88. Telemetry and video monitoring recorded 10 seizures during which the EEG showed flattening of ongoing sharp wave activity in the right frontal region. Electrocorticography further identified and localized epileptogenic tissue in the right frontal cortex and surgical removal of involved tissue and the adjacent two tubers was carried out. Twelve months after surgery the patient has had only two brief seizures.
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| http://dx.doi.org/10.1111/j.1440-1754.1989.tb01465.x | DOI Listing |
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