AI Article Synopsis
- * Out of 141 extracts from 47 different sponge species, 10 exhibited significant inhibitory activity above 85% at a concentration of 1.0 mg/mL.
- * Further testing of 7 promising extracts identified two, Acanthostylotella sp. and Echinodictyum pykei, which demonstrated notably high inhibition (over 60%) at 0.1 mg/mL, with IC50 values of 0.16 and 0.04 mg/mL, respectively, but were inactive at lower concentrations.
Article Abstract
This report describes the use of α-glucosidase to evaluate the anti-diabetic potential of extracts from marine sponges collected in the Mauritius waters. Initial screening at 1.0 mg/mL of 141 extracts obtained from 47 sponge species revealed 10 extracts with inhibitory activity greater than 85%. Seven of the 10 extracts were further tested at 0.1 and 0.01 mg/mL and only the methanol extract of two sponges namely Acanthostylotella sp. (ASSM) and Echinodictyum pykei (EPM) showed inhibition activity greater than 60% at 0.1 mg/mL with an IC50 value of 0.16 ± 0.02 and 0.04 ± 0.01 mg/mL, respectively, while being inactive at 0.01 mg/mL.
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| http://dx.doi.org/10.1080/14786419.2014.945173 | DOI Listing |
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