A 24-year-old female blue and gold macaw (Ara ararauna) was presented for an acute onset of left head tilt. On examination, the macaw was dehydrated and had a 120-degree left head tilt, decreased proprioception of the left pelvic limb, and intermittent vertical nystagmus. Results of hematologic testing and biochemical analysis revealed severe leukocytosis with lymphopenia and heterophilia and a high uric acid concentration. Radiographs showed bilateral intertarsal joint osteoarthritis and a healed ulnar fracture. Magnetic resonance imaging of the brain revealed focal T2 and fluid-attenuated inversion recovery hyperintense lesions in the right cerebral hemisphere and in the midbrain. The midbrain lesion showed susceptibility artifact on the T2* sequence, suggesting hemorrhage. In the T2* sequence, iron accumulation (as seen with hemorrhage) distorts the magnetic signal, resulting in the production of a susceptibility artifact, which can then be visualized as a region of hypointensity. The bird was hospitalized but died despite intensive care. Necropsy revealed multiple cerebral vascular lesions including an acute cerebral infarct, a ruptured midbrain aneurysm, and multifocal systemic atherosclerosis. To our knowledge, this is the first report of a cerebral aneurysm in a bird. This report correlates the clinical presentation, imaging, and histopathologic findings in a macaw with central vestibular disease and demonstrates how advanced imaging techniques can identify hemorrhagic lesions through the T2* sequence.
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http://dx.doi.org/10.1647/2012-069 | DOI Listing |
Mikrochim Acta
January 2025
Department of General Surgery, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, 266035, China.
A lateral flow assay (LFA) was developed for the simultaneous or separate detection of mercury ion and silver ion based on isothermal nucleic acid amplification. T-Hg-T and C-Ag-C were utilized in the isothermal nucleic acid amplification strategy to form specific complementary base pairs. Under the action of KF polymerase and endonuclease Nt.
View Article and Find Full Text PDFAnalyst
January 2025
Department of Chemical and Biological Engineering, Andong National University, Andong, Republic of Korea.
Here, we developed a novel, cost-effective fluorescence light-up biosensor for Pb detection based on a label-free G-quadruplex combined with modified thioflavin T (ThT) derivatives. Among the various G-quadruplex sequences tested, only T2 exhibited fluorescence light-up properties upon interacting with the modified ThT derivatives in the presence of Pb. To enhance the Pb sensing system, we also compared modified ThT derivatives, including the newly synthesized propyl-substituted ThT (ThT-P) and butyl-substituted ThT (ThT-B).
View Article and Find Full Text PDFMagn Reson Med
January 2025
National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Purpose: This study aims to improve the detection of glutamate (Glu) concentration and T using an enhanced transverse relaxation encoding with narrowband decoupling (TREND) technique.
Methods: A new editing pulse was designed to simultaneously invert both Glu H3 spins (2.12 ppm and 2.
Magn Reson Med
January 2025
Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Purpose: To develop a deep subspace learning network that can function across different pulse sequences.
Methods: A contrast-invariant component-by-component (CBC) network structure was developed and compared against previously reported spatiotemporal multicomponent (MC) structure for reconstructing MR Multitasking images. A total of 130, 167, and 16 subjects were imaged using T, T-T, and T-T- -fat fraction (FF) mapping sequences, respectively.
J Assist Reprod Genet
January 2025
Reproductive Medicine Department, Villa Mafalda, Via Monte Delle Gioie 5, 00199, Rome, Italy.
Purpose: Analyze morphokinetic, morphology, and KIDscore™Day5 in different PGT-A classes, focusing on putative mosaicism level and type.
Methods: The single-center retrospective study analyzed 832 embryoscope-cultured blastocysts from cycles with at least one putative mosaic, conducted from 2020 to 2022. A P-value < 0.
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