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Caspase-2 regulates oncogene-induced senescence. | LitMetric

Caspase-2 regulates oncogene-induced senescence.

Oncotarget

Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France; CNRS UMR5286, Lyon, France; Centre Léon Bérard, Lyon, France; Université de Lyon, Lyon, France.

Published: July 2014

AI Article Synopsis

Article Abstract

Cellular senescence is activated by numerous cellular insults, in particular those driving cancer formation, resulting in stable proliferation arrest and acquisition of specific features. By self-opposing to oncogenic stimulation, senescence is considered as a failsafe program, allowing, when functional, to inhibit cancers occurrence. Compelling evidences suggest a tumor suppressive activity of caspase-2, eventually independently of its effect on cell death. The original results described here demonstrate that this tumor suppressive activity of caspase-2 is mediated, at least in part, by its pro-senescing activity. Indeed, we have demonstrated in vitro and in vivo that loss of function of caspase-2 allows to escape oncogenic stress induced senescence. These results are discussed in the context of known tumor suppressive activity of caspase-2.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170627PMC
http://dx.doi.org/10.18632/oncotarget.2286DOI Listing

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