AI Article Synopsis
- EDBD is a sesquiterpene endoperoxide compound previously found in certain plant species in northern Japan, known for its cytotoxic effects and ability to induce apoptosis in leukemia cells.
- The study revealed that EDBD inhibits growth in the yeast Saccharomyces cerevisiae by blocking transitions between critical cell cycle phases (G1 to S and G2 to M).
- EDBD activates stress-response pathways and impacts cyclin activity, which may help in understanding its role in cancer treatment and pave the way for developing EDBD-based therapies.
Article Abstract
Unlabelled: 3,6-Epidioxy-1,10-bisaboladiene (EDBD), a bisabolane sesquiterpene endoperoxide compound, was previously isolated from Cacalia delphiniifolia and C. hastata in northern Japan. EDBD has cytotoxic effects and induces apoptosis via phosphorylation of p38 mitogen-activated protein kinase in human promyelocytic leukemia HL60 cells. However, the mechanism of action of EDBD has not yet been fully elucidated. In this study, we examined the molecular mechanisms of EDBD in the budding yeast Saccharomyces cerevisiae. EDBD arrested the growth of S. cerevisiae cells by suppressing progression from the G1 phase to the S phase and from the G2 phase to the M phase. Moreover, biochemical and genetic analyses revealed that EDBD activated environmental stress-response pathways involving Hog1 and affected Cln3/G1 cyclin activity, thereby inhibiting the expression of SCB-binding factor and MCB-binding factor target genes. Our results provided important insights into the functions of EDBD in tumor cells and may facilitate the development of EDBD-based antitumor therapies.
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| http://dx.doi.org/10.1111/febs.12965 | DOI Listing |
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