Congenital thumb contractures are a well described but complex deformity to manage. Thumb contractures are common in patients with arthrogryposis. Many patients with arthrogryposis develop a supination, adduction, and flexion contracture at the thumb carpometacarpal join. Despite some thumb function, their thumb position and contracted first webspace precludes effective pinch or grasp, with the thumb opposing only to the palmar space. An extension, reorientation metacarpal osteotomy that places thumb in an efficient position has the potential to improve function in of these patients. This report provides a new classification system for congenital thumb deformities that can dictate management based upon thumb joint positions. We describe a previously unreported, arthrogrypotic thumb contracture that can be managed with an extension/pronation metacarpal osteotomy with simultaneous widening of the first webspace.
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Sensors (Basel)
December 2024
Department of Engineering, University of Napoli Parthenope, Centro Direzionale, 80143 Napoli, Italy.
In the context of neurodegenerative diseases, finger tapping is a gold-standard test used by clinicians to evaluate the severity of the condition. The finger tapping test involves repetitive tapping between the index finger and thumb. Subjects affected by neurodegenerative diseases, such as Parkinson's disease, often exhibit symptoms like bradykinesia, rigidity, and tremor.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia.
ORF2p (open reading frame 2 protein) is a multifunctional multidomain enzyme that demonstrates both reverse transcriptase and endonuclease activities and is associated with the pathophysiology of cancer. The 3D structure of the entire seven-domain ORF2p complex was revealed with the recent achievements in structural studies. The different arrangements of the CTD (carboxy-terminal domain) and tower domains were identified as the "closed-ring" and "open-ring" conformations, which differed by the hairpin position of the tower domain, but the structural diversity of these complexes has the potential to be more extensive.
View Article and Find Full Text PDFRMD Open
January 2025
Health Services Research and Innovation Unit, Diakonhjemmet Hospital, Oslo, Norway.
Background: We aimed to update the 2018 systematic literature review on the efficacy and safety of treatments for hand osteoarthritis (OA), which was based on 126 studies.
Methods: We performed a systematic literature search on randomised controlled trials from June 2017 up to 31 December 2023. Risk of bias was assessed using the RoB2 tool.
Hand Surg Rehabil
January 2025
Chirurgie de la Main et de la Membre supérieur, Médipôle 1 rue Jules Méline, 51430 Bezannes, France.
Trigger finger, or stenosing tenovaginitis, is a common condition characterized by impaired flexor tendon sliding due to thickening of the A1 pulley. While open surgical release remains the gold standard for the treatment of persistent trigger finger, there is increasing interest in minimally invasive ultrasound-guided techniques to improve precision and outcomes. The purpose of this study is to evaluate the outcomes, safety, and complications associated with ultrasound-guided trigger finger release using a minimally invasive surgical knife.
View Article and Find Full Text PDFNat Commun
January 2025
Data Science Institute, Imperial College London, London, UK.
AI techniques are increasingly being used to identify individuals both offline and online. However, quantifying their effectiveness at scale and, by extension, the risks they pose remains a significant challenge. Here, we propose a two-parameter Bayesian model for exact matching techniques and derive an analytical expression for correctness (κ), the fraction of people accurately identified in a population.
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