AI Article Synopsis
- The study investigated the presence of antineuronal antibodies in 103 psychiatric inpatients and 41 control subjects without malignancies or neurological issues.
- Indirect immunofluorescence testing revealed 20 patients had antineuronal nuclear autoantibodies, while some had antibodies reacting with Purkinje cell cytoplasm, but none of the controls showed similar results.
- Over a 5-year follow-up, the five patients with confirmed antibodies did not develop any neurological disorders or cancers.
Article Abstract
The authors aimed to determine the prevalence of antineuronal antibodies in 103 psychiatric inpatients and 41 control subjects with no history of malignancies or neurological disorders. All sera were tested by indirect immunofluorescence and positive sera by immunoblot. Using immunofluorescence, antineuronal nuclear autoantibodies were detected in 20 patients and none of the control subjects, and antibodies reacted with the cytoplasm of Purkinje cells in six patients and two control subjects. The immunoblot confirmed well-characterized antineuronal antibodies only in five patients: two had anti-Ri and three had anti-Yo antibodies. After a follow-up of 5 years, none of these patients developed neurological disorder or malignancy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1176/appi.neuropsych.13070153 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!