Canthaxanthine retinopathy is a crystalline retinopathy that follow oral ingestion of canthaxanthine-containing drugs. We describe the clinical course of a patient with canthaxanthine retinopathy and preexisting idiopathic macular pucker over a period of 2.5 years. Light microscopic investigation of the macular pucker revealed a fibrocellular membrane containing granular, birefringent material and vacuoles within the cells of the membrane resulting from canthaxanthine deposits in the epiretinal membrane. Long-term follow-up shows a slight, but significant, reduction of the retinal crystals.

Download full-text PDF

Source

Publication Analysis

Top Keywords

canthaxanthine retinopathy
8
macular pucker
8
[canthaxanthin retinopathy
4
macular
4
retinopathy macular
4
macular pucker--clinical
4
pucker--clinical picture
4
picture ultrastructural
4
ultrastructural findings
4
findings macular
4

Similar Publications

This study will provide a thorough review of systemic (and select intravitreal) medications, along with illicit drugs that are capable of causing various patterns of retinal toxicity. The diagnosis is established by taking a thorough medication and drug history, and then by pattern recognition of the clinical retinal changes and multimodal imaging features. Examples of all of these types of toxicity will be thoroughly reviewed, including agents that cause retinal pigment epithelial disruption (hydroxychloroquine, thioridazine, pentosan polysulfate sodium, dideoxyinosine), retinal vascular occlusion (quinine, oral contraceptives), cystoid macular edema/retinal edema (nicotinic acid, sulfa-containing medications, taxels, glitazones), crystalline deposition (tamoxifen, canthaxanthin, methoxyflurane), uveitis, miscellaneous, and subjective visual symptoms (digoxin, sildenafil).

View Article and Find Full Text PDF

Limited information is known about the extent of canthaxanthin crystalline retinopathy on the retinal layers. The authors describe a 51-year-old woman who was taking canthaxanthin for tanning purposes for 7 years. Three years after cessation of this agent, she presented with asymmetric crystalline retinopathy affecting both eyes.

View Article and Find Full Text PDF

Retinal toxicity due to canthaxanthin. Case series.

Arch Soc Esp Oftalmol (Engl Ed)

August 2018

Departamento de Oftalmología, Hospital Italiano de Buenos Aires, , Buenos Aires, Argentina.

Introduction: Canthaxanthin is a chemical product used to tan the skin. Its most frequent adverse effect is canthaxanthin retinopathy.

Purpose/ Methods: Report, case series.

View Article and Find Full Text PDF

Purpose: To analyze macular pigment (MP) amount and distribution in patients with macular telangiectasia Type 2 receiving oral zeaxanthin supplementation in a randomized, open-label, interventional trial.

Methods: Eight macular telangiectasia Type 2 patients were randomized to 10 mg or 20 mg of zeaxanthin per day. At each visit, best-corrected visual acuity, contrast sensitivity, fundus biomicroscopy, color fundus photography, autofluorescence imaging, optical coherence tomography, and serum carotenoid levels were tested.

View Article and Find Full Text PDF

Multifocal electroretinography (mfERG) is an objective, noninvasive examination for the assessment of visual function. It enables the stimulation of multiple retinal areas simultaneously and recording of each response independently, providing a topographic measure of retinal electrophysiological activity in the central 40-50° of the retina. A clinical application of mfERG represents the assessment of retinal toxicity associated with systemic medications.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!