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Decoding RAS isoform and codon-specific signalling. | LitMetric

Decoding RAS isoform and codon-specific signalling.

Biochem Soc Trans

*Division of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, U.K.

Published: August 2014

RAS proteins are key signalling hubs that are oncogenically mutated in 30% of all cancer cases. Three genes encode almost identical isoforms that are ubiquitously expressed, but are not functionally redundant. The network responses associated with each isoform and individual oncogenic mutations remain to be fully characterized. In the present article, we review recent data defining the differences between the RAS isoforms and their most commonly mutated codons and discuss the underlying mechanisms.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961500PMC
http://dx.doi.org/10.1042/BST20140057DOI Listing

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