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Active-reset protein sensors enable continuous in vivo monitoring of inflammation.
Science
December 2024
Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, USA.
Continuous measurement of proteins in vivo is important for real-time disease management and prevention. Implantable sensors for monitoring small molecules such as glucose have been available for more than a decade. However, analysis of proteins remains an unmet need because the lower physiological levels require that sensors have high affinities, which are linked to long complexation half-lives ( ~20 hours) and slow equilibration when concentrations decrease.
View Article and Find Full Text PDFAssociation Between Standard Gait Measures and Anterior Quadriceps Muscle Thickness as Measured by Point of Care Ultrasound (POCUS).
POCUS J
November 2024
Department of Medicine, Division of Geriatric Medicine, University of British Columbia Vancouver, BC CAN.
Gait parameters and sarcopenia both predict falls risk among older adults. Our objective was to evaluate whether fast, easy-to-obtain measures of anterior thigh muscle by point of care ultrasound (POCUS) are significantly associated with standard gait measures. All subjects were referred from ambulatory geriatric medicine clinics at an academic center.
View Article and Find Full Text PDFIn this pre-specified sub-study of the POISE-3 trial, we examined the effect of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of postoperative acute kidney injury (AKI). Altogether, 7307 patients were included from 110 hospitals in 22 countries. Patients were 45 years and older, had or were at risk of atherosclerotic disease, took at least one antihypertensive medication, and were scheduled for noncardiac surgery.
View Article and Find Full Text PDFPropofol and Fentanyl Pharmacokinetics and Pharmacodynamics in Extracorporeal Membrane Oxygenation.
Ann Am Thorac Soc
October 2024
University of Toronto, Interdepartmental Division of Critical Care Medicine, Toronto, Ontario, Canada.
Article Synopsis
- - This study investigates how the medications propofol and fentanyl behave in the body (PK/PD) in patients using veno-venous extracorporeal membrane oxygenation (V-V ECMO) due to a lack of existing data in this area.
- - Conducted at Toronto General Hospital ICU, the research involved 11 patients monitored over a median of 146 hours, revealing that both medications follow a two-compartment model for clearance and that over-sedation was common despite increased clearance rates shortly after ECMO began.
- - Results show that while clearance of sedatives increased temporarily after ECMO initiation and differences were noted based on sex, sedation effectiveness varied and respiratory effort was inconsistent regardless of medication levels.
Evaluating Learning by Assessing Patient Outcomes in a Student Pro Bono Clinic: A Case Report.
J Phys Ther Educ
September 2024
Amy M. Yorke is a professor in the Physical Therapy Department at the University of Michigan-Flint, 303 East Kearsley Street, 2157 William S. White, Flint, MI 48502 Please address all correspondence to Amy M. Yorke.
Background And Purpose: In 2020, a clinical practice guideline (CPG) highly recommended high-intensity gait training (HIGT) to improve walking outcomes in adults with chronic stroke, incomplete spinal cord injury (SCI), and brain injury. The success of implementing a CPG into a student-run pro bono clinic (SRPBC) utilizing knowledge translation (KT) to assess student learning is not well described. The purpose of this case report is to describe student learning by assessing the fidelity of HIGT implementation (time spent in HIGT and level of cardiovascular intensity) in a SRPBC.
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