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Altered oxidative stress/antioxidant status in blood of alcoholic subjects is associated with alcoholic liver disease. | LitMetric

Altered oxidative stress/antioxidant status in blood of alcoholic subjects is associated with alcoholic liver disease.

Drug Alcohol Depend

DISTAV, Dipartimento di Scienze della Terra, dell'Ambiente e della Vita, Università di Genova, Corso Europa 26, 16132, Genova, Italy; INBB, Istituto Nazionale Biostrutture e Biosistemi, Roma, Italy. Electronic address:

Published: October 2014

AI Article Synopsis

  • The study explores the link between oxidative stress and alcoholic liver disease (ALD), examining erythrocyte oxidative stress indices, leukocyte antioxidant proteins, and liver health metrics in a group of alcoholic and control subjects.
  • Researchers found that alcoholic individuals exhibited higher body mass index, liver fat accumulation, and abnormal blood chemistry, indicating significant liver damage and oxidative stress markers.
  • The findings suggest that changes in blood metallothioneins, alongside a new scoring algorithm (HePaTest), could serve as a non-invasive method for assessing and monitoring alcohol-related liver damage in patients.

Article Abstract

Background: Oxidative stress is implicated in pathogenesis of alcoholic liver disease (ALD). This study investigated the possible correlation among the erythrocyte indices of oxidative stress, the leukocyte panels of antioxidant proteins (metallothioneins), the serum biochemical parameters and the liver steatosis grade.

Methods: A total of 118 cases including 60 alcoholic subjects and 58 controls were enrolled. All the alcoholic subjects were screened for body mass index (BMI), liver steatosis, and blood chemistry and serology. The level of oxidative stress and oxidative stress-related parameters were measured in the blood and correlated with clinical findings.

Results: Alcoholic subjects showed higher BMI, moderate/severe hepatic steatosis, increase in the levels of triglycerides, cholesterol, glucose, γ-glutamyl-transpeptidase (GGT), alanine aminotransferase (ALT), bilirubin, alpha 1 and beta 2 globulins, iron and a decrease in the levels of aspartate aminotransferase (AST) and beta 1 globulin with respect to the reference values. Moreover, alcoholic subjects showed: (i) an increase in Thiobarbituric Acid Reactive Substance (TBARS) content representing a good estimation of global oxidative stress; (ii) a stimulation of the activities of the antioxidant enzymes catalase and SOD; (iii) a modulation of expression of metallothioneins, with a down-regulation of MT-1A and an up-regulation of MT-1E isoforms.

Conclusions: Our data suggest that alcoholism is strongly associated with altered pattern of blood metallothioneins; this parameter combined with the score calculated by an ad hoc implemented algorithm (HePaTest) could offer a non-invasive alternative approach for evaluating alcohol-related damages and could be used in follow-up of alcoholic patients.

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Source
http://dx.doi.org/10.1016/j.drugalcdep.2014.07.013DOI Listing

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