Nanoparticles mediated vaccine delivery is an emerging technology and considered as better adjuvant for delivering vaccines when compared to conventional delivery system. The purpose of this delivery system is to provide simple stable formulation that elicits lifelong immunity preferably with single shot. In line to develop the biodegradable polymer vaccine delivery system it is necessary to understand about the nature of polymer, type of antigen to be encapsulated, broad idea about immunological sketch. In this review, we attempt to provide an overview about the nano particle vaccine delivery system and interaction between nano particle and the immune system.
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