Chemical constituents of EtOAc extract from the rhizomes of traditional Chinese medicine Qian-nian-jian (Homalomena occulta) have been studied, a new sesquiterpenoid, named euadesma-4-ene-1β,15-diol (1), and four related known compounds, polydactin B (2), oplodiol (3), 1β,4β,7α-trihydroxyeudesmane (4), and (-)1β,4β,6α-trihydroxy-eudesmane (5), were isolated. Their structures were elucidated using spectroscopic methods including 1D and 2D NMR techniques and mass spectrometry. All the isolates were tested against the human lung adenocarcinoma A549 using MTT assay method. Oplodiol (3) and (-)1β,4β,6α-trihydroxy-eudesmane (5) were found to show moderate cytotoxic effects on A549 with IC50 values at 25.5 and 15.0 μg/mL, respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2014.934238 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characterization of the complete chloroplast genome of (Lour.) Schott.
Mitochondrial DNA B Resour
March 2021
College of Medicine, Pingdingshan University, Pingdingshan City, Henan Province, China.
(Lour.) Schott () is a traditional Chinese medicine. However, the chloroplast genome has not been reported.
View Article and Find Full Text PDFFurther sesquiterpenoids from the rhizomes of Homalomena occulta and their anti-inflammatory activity.
Bioorg Med Chem Lett
May 2019
CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China. Electronic address:
The rhizomes of Homalomena occulta are called Qian-nian-jian in Traditional Chinese Medicine (TCM), which is widely consumed in China owing to its health benefits for the treatment of rheumatoid arthritis and for strengthening tendons and bones. A phytochemical investigation on this famous TCM yielded 19 sesquiterpenoids (1-19) with various carbocyclic skeletons including isodaucane (2, 8, and 9), guaiane (3), eudesmane (4 and 10-15), oppositane (5, 16, and 17), and aromadendrane (18 and 19) types. The structures of new compounds, Homalomenins A-E (1-5), were determined by diverse spectroscopic data.
View Article and Find Full Text PDFPurification, characterization, crystal structure and NO production inhibitory activity of three new sesquiterpenoids from homalomena occulta.
Acta Crystallogr C Struct Chem
November 2018
School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Guanhai Road 346#, Yantai, Shandong 264003, People's Republic of China.
Two new isodaucane-type sesquiterpenoids, namely (1R,4S,5S,6R,7S,10R)-isodauc-6,7,10-triol, CHO, (1), and (1R,4S,5S,6S,7S,10R)-isodauc-6,7,10-triol, (2), and a new eudesmane-type sesquiterpenoid, 1β,4β,5α-trihydroxyeudesmane, (3), were obtained from the rhizomes of homalomena occulta with the aid of column chromatography. Their structures were elucidated based on extensive spectroscopic analyses, including 1D NMR, 2D NMR and HRESIMS. The structure of (1) was confirmed by single-crystal X-ray diffraction and the absolute configuration was assigned with respect to that of the precursor.
View Article and Find Full Text PDF[Online Analysis of Dynamic Trend Regression and Endpoint Determination for Chinese Traditional Medicine Extraction Process Based on Ultraviolet spectroscopy].
Guang Pu Xue Yu Guang Pu Fen Xi
February 2017
With the transition of Chinese traditional medicine manufacture industry, modernization has become the inexorable tendency in its future development. However, during the current Chinese traditional medicine producing process, the lack of online monitoring leads to the lagging of quality detection, as well as quality differences between products. In this paper, aiming at realizing online monitoring and end point automatic determination for Chinese traditional medicine (CTM) extraction unit, which is one of the most important units in CTM producing, ultraviolet (UV) spectroscopy is applied to build UV absorbance dynamic model based on the Lambert-Beer law and the CTM extraction kinetic model which presents a new method of UV absorbance dynamic analysis and endpoint determination, including curve regression, robustness analysis and endpoint calculation.
View Article and Find Full Text PDFSesquiterpenoids from the Rhizomes of Homalomena occulta.
Nat Prod Bioprospect
August 2016
Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, People's Republic of China.
Naturally occurring oplopanane sesquiterpenoids are rarely reported. A phytochemical investigation on the rhizomes of Homalomena occulta (Lours) has resulted in the discovery of six oplopanane sesquiterpenoids (1-6), including four new (1-4) and one 3,5-seco-oplopanane (6), together with three previously reported sesquiterpenoids (7-9). In addition three new oplopananes (2a-4a) were also obtained by chemical transformation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!