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Predicting Unilateral Aldosterone Secretion in Primary Aldosteronism.
J Surg Res
December 2024
Division of Endocrine and Oncologic Surgery, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
Introduction: Primary aldosteronism affects 20% of patients with resistant hypertension and may be due to unilateral or bilateral causes. Patients with a unilateral source of aldosterone secretion are potentially curable with adrenalectomy. Adrenal vein sampling (AVS) is the definitive test for subtype differentiation but may not be accessible outside tertiary centers.
View Article and Find Full Text PDFEvolution of mineralocorticoid receptor antagonists, aldosterone synthase inhibitors, and alternative treatments for managing primary aldosteronism.
Hypertens Res
November 2024
Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Oita, Japan.
Primary aldosteronism (PA) is a prevalent and curable secondary hypertensive disorder that accounts for 5-13% of all hypertension cases. The prevalence of resistant hypertension, cerebral and cardiovascular diseases, and renal complications is higher in PA patients than in those with essential hypertension. Appropriate diagnosis and treatment at an early stage may suppress cerebral and cardiovascular events.
View Article and Find Full Text PDFDeficiency of adenosine deaminase 2 (DADA2) presented with bilateral renal subcapsular hematoma: a case report and literature review.
Ann Med Surg (Lond)
November 2024
Palestine Medical Complex, Internal Medicine, Ramallah, State of Palestine.
Article Synopsis
- Adenosine deaminase 2 (DADA2) deficiency is an autoinflammatory disease caused by mutations in the ADA2 gene, leading to various symptoms and potential complications like renal subcapsular hematoma.
- An 18-year-old female with a history of optic neuritis experienced severe flank pain and inflammatory symptoms, and imaging confirmed bilateral renal subcapsular hematomas, leading to the consideration of DADA2 based on her symptoms and family history.
- The patient was treated successfully with immunosuppressives, resulting in significant improvement and reduction of the hematomas, highlighting the importance of early diagnosis and treatment in managing DADA2 effectively.
The outcomes of children with primary malignant renal tumors: a 14-year single-center experience.
BMC Cancer
November 2024
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Wilms tumor (WT) is the most common malignant renal tumor in children. This study investigated the clinical features, pathological findings, and outcomes of children with malignant renal tumors in Southern Iran. Factors associated with recurrence and mortality were assessed.
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