Ameloblastoma occurs in a wide variety of forms. Various forms of ameloblastomas have various treatment modalities ranging from a conservative approach to surgical resection with reconstruction. We report a case of unicystic ameloblastoma with mural proliferation in a 17-year-old girl, who presented with a swelling in the lower left jaw associated with dull aching pain and was managed initially by a conservative approach followed by surgical enucleation on recurrence.
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http://dx.doi.org/10.1136/bcr-2014-206273 | DOI Listing |
J Clin Exp Dent
December 2024
Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Srinakharinwirot University.
Background: N6-methyladenosine (m6A), the most abundant internal RNA modification in mammals, plays a critical role in many forms of cancer. Methyltransferase-like 3 (METTL3) serves as the main catalytic subunit of the m6A writer and plays a role in the progression of head and neck squamous cell carcinoma. To date, the role of METTL3 in odontogenic lesions has never been investigated.
View Article and Find Full Text PDFHead Neck Pathol
December 2024
Institute of Pathology, Sheba Medical Center, Tel Hashomer, 5265601, Israel.
Purpose: Current standard of care for ameloblastoma (conventional/unicystic - mural type) usually mandates extensive bone resection that frequently necessitates immediate reconstruction with serious sequelae, especially among young patients. BRAF-mutated ameloblastomas can be targeted by BRAF inhibitors to markedly reduce their size, enabling conservative removal of residual tumor. We aimed to characterize the effect of post-treatment histomorphologic changes.
View Article and Find Full Text PDFAppl Immunohistochem Mol Morphol
November 2024
Department of Basic Sciences, College of Dentistry, Princess Nourah bint Abdulrahman University, 84428, Riyadh 11671, Saudi Arabia.
Odontogenic cysts and tumors exhibit a broad spectrum of biological characteristics. Despite recent advances in understanding the complex nature of these lesions, relatively less is known about the molecular markers involved in key pathogenic steps, such as proliferation and differentiation. This study aimed to elucidate the expression patterns of p63 and Ki-67 in odontogenic lesions, which may influence the management strategies.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
December 2024
Department of Oral Medicine and Radiology, Government Dental College and Hospital, Srinagar, India.
Glandular odontogenic cysts(GOC) are among the rarest odontogenic cysts defined by the presence of glandular epithelium in the epithelial lining posing some diagnostic difficulties. GOC associated with ameloblastoma is extremely rare with only 5 cases reported. This report deals with this rare occurrence of GOC along with unicystic ameloblastoma.
View Article and Find Full Text PDFSemin Diagn Pathol
November 2024
Professor and Head, Department of Oral Pathology & Microbiology, King George's Medical, University, Lucknow 226003, UP, India. Electronic address:
Ameloblastoma is a true benign odontogenic epithelial tumor, primarily arising in the jaw, and ranks as the second most prevalent odontogenic neoplasm following odontoma. Known for its diverse clinical, radiographic, and histological manifestations, ameloblastoma encompasses a wide spectrum of presentations. Unicystic ameloblastomas (UAs), a less common and generally less aggressive variant, appear as cystic lesions that can mimic ordinary jaw cysts in their clinical and radiologic features.
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