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The Golgi ribbon structure facilitates anterograde transport of large cargoes. | LitMetric

AI Article Synopsis

Article Abstract

In mammalian cells, individual Golgi stacks fuse laterally to form the characteristic perinuclear ribbon structure. Yet the purpose of this remarkable structure has been an enigma. We report that breaking down the ribbon of mammalian cells strongly inhibits intra-Golgi transport of large cargoes without altering the rate of transport of smaller cargoes. In addition, insect cells that naturally harbor dispersed Golgi stacks have limited capacity to transport artificial oversized cargoes. These results imply that the ribbon structure is an essential requirement for transport of large cargoes in mammalian cells, and we suggest that this is because it enables the dilated rims of cisternae (containing the aggregates) to move across the stack as they transfer among adjacent stacks within the ribbon structure.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230591PMC
http://dx.doi.org/10.1091/mbc.E14-04-0931DOI Listing

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