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Presumed gabapentin-induced myoclonus in two cats.
JFMS Open Rep
November 2024
Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, OH, USA.
Article Synopsis
- Two cats with chronic kidney disease experienced myoclonus after receiving gabapentin, an effect previously noted in humans but undocumented in felines.
- Both cats had a history of seizures and were administered gabapentin to reduce anxiety prior to their veterinary visits, where they exhibited unusual head jerking separate from prior seizure activity.
- This case highlights the need for veterinary awareness of gabapentin's potential adverse effects in cats, particularly in those with kidney disease, indicating the need for further research on risk factors.
Gabapentin-induced Multifocal Myoclonus.
J Assoc Physicians India
August 2024
Assistant Professor, Department of Neurology, MS Ramaiah Medical College, Ramaiah University of Applied Sciences (RUAS), Bengaluru, Karnataka, India.
Background: Gabapentin is the most commonly preferred agent for neuropathic pain in general practice as it is usually well tolerated, but occasionally, its toxicity may occur at standard doses, especially in elderly individuals, even without any prior comorbidities.
Case: We present an elderly male with normal renal parameters, who was started on gabapentin for neuropathic pain. He developed multifocal myoclonus all over the body within few days after starting gabapentin and subsided completed after withdrawal of the drug.
Gabapentin-Induced Myoclonus in a Patient With Chronic Kidney Disease.
Cureus
October 2023
Internal Medicine, State University of New York Downstate Health Sciences University, Brooklyn, USA.
Gabapentin contains a cyclohexyl group and is a form of gamma-aminobutyric acid (GABA). Despite its name, gabapentin does not affect the inhibitory neurotransmitter GABA or its receptors. Instead, it acts as a ligand, binding strongly to the α2δ (Ca) channel subunit and interfering with its regulatory function and the release of excitatory neurotransmitters.
View Article and Find Full Text PDFGabapentin-Induced Myokymia: A Case Report.
Clin Neuropharmacol
October 2021
Department of Neurology, University of Texas Medical Branch, Galveston, TX.
Background: Gabapentin is a commonly used medication for neuropathic pain and epilepsy that is prescribed by a wide range of medical specialties. Adverse effects including asterixis and myoclonus have been described in patients with chronic kidney disease, but myokymia has not been previously reported.
Case Presentation: A 69-year-old man with a history of traumatic brain injury, peripheral neuropathy, amnesia, and posttraumatic stress disorder presented to the hospital after multiple falls attributed to acute onset muscle spasms.
Gabapentin-induced Facial Myoclonus in the Setting of Acute on Chronic Kidney Disease.
Cureus
May 2019
Emergency Medicine, OhioHealth Doctors Hospital, Columbus, USA.
An 82-year-old male with chronic kidney disease presented to the emergency department with sudden onset of left sided facial myoclonus. Myoclonus is a rare, but known side effect of gabapentin; however, there does not appear to be documented cases of gabapentin-induced facial myoclonus described in the emergency medicine literature. This case discusses the emergency department evaluation and inpatient treatment of gabapentin-induced facial myoclonus in the setting of acute on chronic kidney disease.
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