The antioxidant effect of melatonin on the blood oxygen transport and prooxidant-antioxidant balance during with hepatic ischemia-reperfusion (HIR) with inhibited NO synthase function has been studied in male Wistar rats. The animals were divided into 4 groups: (1) control; (2) hepatic ischemia (Pringle m., 30 min) and reperfusion for 120 min (HIR, n = 9); (9) HIR with melatonin (10 mg/kg, i.p., 10 min before HIR, n = 9); and (4) same with NO inhibitor (L-NAME, 10 mg/kg) added 5 min before melatonin administration. The indices of blood oxygen transport (p50act, pCO2, pH, pO2, etc.) and prooxidant-antioxidant balance (Schiff bases, conjugated dienes, catalase, retinol, alpha-tocopherol) were measured in blood and liver. HIR in group 1 resulted in higher p50act in mixed venous blood and sever oxidative disturbances: rise of CD and SB, decrease of alpha-T, Ret, and Cat. Melatonin in group 3 significantly improved these changes in p50act and prooxidant-antioxidant balance during HIR, but L-NAME in group 4 partly eliminated this effect. It is concluded that the antioxidant effect of melatonin during HIR is partly associated with NO-depended mechanisms, which can modify blood hemoglobin affinity to oxygen, thus limiting oxygen binding in free-radical processes.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Effects of propolis supplementation on prooxidant-antioxidant balance, oxidative stress biomarkers, and body composition in obese patients with NAFLD: A double-blind randomized controlled clinical trial.
Health Promot Perspect
October 2024
Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Article Synopsis
- Oxidative stress plays a crucial role in the development of non-alcoholic fatty liver disease (NAFLD), and this study examined the antioxidant properties of Iranian propolis (PRP) on obese NAFLD patients.
- A double-blind clinical trial involving 44 patients compared the effects of PRP (1500 mg/d) and a placebo over eight weeks, assessing oxidative stress biomarkers and body composition.
- Results showed that while PRP helped maintain serum glutathione peroxidase levels compared to placebo, it did not significantly affect other oxidative stress markers, body composition, or dietary intake.
Geroprotective effects of GdVO:Eu nanoparticles, metformin and calorie restriction in male rats with accelerated aging induced by overnutrition in early postnatal ontogenesis.
Biogerontology
November 2024
Karazin Kharkiv National University, Svobody Square, 4, Kharkiv, 61022, Ukraine.
GdVO:Eu nanoparticles (OVNPs) have previously been shown to exhibit anti-aging effects in old rats.The accelerated aging model (overnutrition in early postnatal ontogenesis (POF)) was used to confirm the effect of OVNPs as a potential geroprotector. A comparative study of the effect of OVNPs, calorierestriction (CR) and CR-mimetic-metformin was carried out using a number of criteria: survival, prooxidant-antioxidant balance in the liver and blood, physiological parameters of male Wistar rats with accelerated aging.
View Article and Find Full Text PDF[Evaluation of the effect of the antioxidant complex on the processes of lipid peroxidation and antioxidant protection in men with impaired spermatogenesis who underwent a new coronavirus infection COVID-19].
Urologiia
November 2024
FSPSI Scientific center for family health and human reproduction problems, Irkutsk, Russia.
Unlabelled: Reactive oxygen species are secondary messengers in multiple intracellular and tissue reactions, modulate the activity of mitogenic signaling pathways, and are formed predominantly in the course of metabolic activity. Both direct and indirect data on male reproductive dysfunction associated with SARSCoV-2 are described, as well as its possible pathophysiological and immunological explanations.
Purpose: of the work: to evaluate the dynamics of lipid peroxidation and antioxidant protection in men after SARS-CoV-2 infection while taking an antioxidant complex.
The effect of Fenugreek seed dry extract supplement on glycemic indices, lipid profile, and prooxidant-antioxidant balance in patients with type 2 diabetes: A double-blind randomized clinical trial.
J Cardiovasc Thorac Res
September 2024
Nutrition Research Center, Department of Clinical Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Introduction: This study aims to determine the effects of fenugreek seed dry extract (FDE) on the glycemic indices, lipid profile, and prooxidant-antioxidant balance (PAB) in patients with type 2 diabetes (T2D).
Methods: A double-blind randomized clinical trial was carried out on 54 individuals with T2D. Participants were randomly assigned to a FDE group (received 3 tablets containing 335 mg of FDE daily for 8 weeks) or a placebo group (received tablets containing microcrystalline cellulose).
Anti-oxidative activity of probiotics; focused on cardiovascular disease, cancer, aging, and obesity.
Microb Pathog
November 2024
Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran. Electronic address:
By disturbing the prooxidant-antioxidant balance in the cell, a condition called oxidative stress is created, causing severe damage to the nucleic acid, protein, and lipid of the host cell, and as a result, endangers the viability of the host cell. A relationship between oxidative stress and several different diseases such as cardiovascular diseases, cancer, and obesity has been reported. Therefore, maintaining this prooxidant-antioxidant balance is vital for the cell.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!